2-(3-(2-((S)-1-((S)-2-((R)-1-(bis(4-(methylthio)phenoxy)-phosphoryl)-2-methylpropylcarbamoyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylamino)-2-oxoethyl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)acetic acid

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Chemical Name:2-(3-(2-((S)-1-((S)-2-((R)-1-(bis(4-(methylthio)phenoxy)-phosphoryl)-2-methylpropylcarbamoyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylamino)-2-oxoethyl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)acetic acid
CAS No.:1387563-89-4
Molecular Formula:C₃₇H₄₈N₅O₁₀PS₂
Molecular Weight:817.921
Hs Code.:

2-(3-(2-((S)-1-((S)-2-((R)-1-(bis(4-(methylthio)phenoxy)-phosphoryl)-2-methylpropylcarbamoyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylamino)-2-oxoethyl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)acetic acid

Synonyms:2-(3-(2-((S)-1-((S)-2-((R)-1-(bis(4-(methylthio)phenoxy)-phosphoryl)-2-methylpropylcarbamoyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylamino)-2-oxoethyl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)acetic acid

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Chemical Property of 2-(3-(2-((S)-1-((S)-2-((R)-1-(bis(4-(methylthio)phenoxy)-phosphoryl)-2-methylpropylcarbamoyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylamino)-2-oxoethyl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)acetic acid

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Technology Process of 2-(3-(2-((S)-1-((S)-2-((R)-1-(bis(4-(methylthio)phenoxy)-phosphoryl)-2-methylpropylcarbamoyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylamino)-2-oxoethyl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)acetic acid

There total 10 articles about 2-(3-(2-((S)-1-((S)-2-((R)-1-(bis(4-(methylthio)phenoxy)-phosphoryl)-2-methylpropylcarbamoyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylamino)-2-oxoethyl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1387563-87-2
tert-butyl 2-(3-(2-((S)-1-((S)-2-((R)-1-(bis(4-(methylthio)phenoxy)-phosphoryl)-2-methylpropylcarbamoyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylamino)-2-oxoethyl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)acetate

: 1387563-89-4
2-(3-(2-((S)-1-((S)-2-((R)-1-(bis(4-(methylthio)phenoxy)-phosphoryl)-2-methylpropylcarbamoyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylamino)-2-oxoethyl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)acetic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 22 ℃; for 2h;
DOI:10.1021/jm300599x

Reference yield:

: bis(4-(methylthio)phenyl) 1-amino-2-methylpropylphosphonate hydrobromide

: 1387563-89-4
2-(3-(2-((S)-1-((S)-2-((R)-1-(bis(4-(methylthio)phenoxy)-phosphoryl)-2-methylpropylcarbamoyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylamino)-2-oxoethyl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 22 °C

2: dichloromethane / 2 h / 22 °C

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 22 °C

4: Resolution of racemate

5: dichloromethane / 2 h / 22 °C

6: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 22 °C

7: trifluoroacetic acid / dichloromethane / 2 h / 22 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1021/jm300599x

Reference yield:

: (2S)-tert-butyl 2-(1-(bis(4-(methylthio)phenoxy)phosphoryl)-2-methylpropylcarbamoyl)pyrrolidine-1-carboxylate

: 1387563-89-4
2-(3-(2-((S)-1-((S)-2-((R)-1-(bis(4-(methylthio)phenoxy)-phosphoryl)-2-methylpropylcarbamoyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylamino)-2-oxoethyl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: dichloromethane / 2 h / 22 °C

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 22 °C

3: Resolution of racemate

4: dichloromethane / 2 h / 22 °C

5: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 22 °C

6: trifluoroacetic acid / dichloromethane / 2 h / 22 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1021/jm300599x