[4-(4-{4-[(S)-2-(Bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-butoxy)-5-methoxy-2-nitro-phenyl]-[(S)-2-(bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidin-1-yl]-methanone

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Chemical Name:[4-(4-{4-[(S)-2-(Bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-butoxy)-5-methoxy-2-nitro-phenyl]-[(S)-2-(bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidin-1-yl]-methanone
CAS No.:808154-82-7
Molecular Formula:C₄₀H₅₀F₄N₄O₁₀S₄
Molecular Weight:951.115
Hs Code.:

[4-(4-{4-[(S)-2-(Bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-butoxy)-5-methoxy-2-nitro-phenyl]-[(S)-2-(bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidin-1-yl]-methanone

Synonyms:[4-(4-{4-[(S)-2-(Bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-butoxy)-5-methoxy-2-nitro-phenyl]-[(S)-2-(bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidin-1-yl]-methanone

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Chemical Property of [4-(4-{4-[(S)-2-(Bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-butoxy)-5-methoxy-2-nitro-phenyl]-[(S)-2-(bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidin-1-yl]-methanone

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Technology Process of [4-(4-{4-[(S)-2-(Bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-butoxy)-5-methoxy-2-nitro-phenyl]-[(S)-2-(bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidin-1-yl]-methanone

There total 11 articles about [4-(4-{4-[(S)-2-(Bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-butoxy)-5-methoxy-2-nitro-phenyl]-[(S)-2-(bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidin-1-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 808154-82-7
[4-(4-{4-[(S)-2-(Bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-butoxy)-5-methoxy-2-nitro-phenyl]-[(S)-2-(bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidin-1-yl]-methanone

Guidance literature:: Multi-step reaction with 9 steps

1: 100 percent / aq. NaOH / tetrahydrofuran / 20 °C

2: trichloroisocyanuric acid; TEMPO / CH₂Cl₂

3: HMPT; Zn / tetrahydrofuran

4: TFA / CH₂Cl₂

5: Et₃N / dimethylformamide; tetrahydrofuran

6: 85 percent / DIBAL-H / CH₂Cl₂ / 0.75 h / -78 °C

7: 90 percent / TMSCl / CHCl₃ / 24 h / 20 °C

8: 80 percent / EtSH-BF₃OEt₂ / CH₂Cl₂ / 12 h / 20 °C

9: K₂CO₃ / acetone / Heating

With N,N,N,N,N,N-hexamethylphosphoric triamide; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hydroxide; chloro-trimethyl-silane; trichloroisocyanuric acid; boron trifluoride diethyl etherate; diisobutylaluminium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; ethanethiol; zinc; In tetrahydrofuran; dichloromethane; chloroform; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmcl.2004.08.050

Reference yield:

: 64154-78-5
4-benzyloxy-5-methoxy-2-nitrobenzoyl chloride

: 808154-82-7
[4-(4-{4-[(S)-2-(Bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-butoxy)-5-methoxy-2-nitro-phenyl]-[(S)-2-(bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidin-1-yl]-methanone

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / dimethylformamide; tetrahydrofuran

2: 85 percent / DIBAL-H / CH₂Cl₂ / 0.75 h / -78 °C

3: 90 percent / TMSCl / CHCl₃ / 24 h / 20 °C

4: 80 percent / EtSH-BF₃OEt₂ / CH₂Cl₂ / 12 h / 20 °C

5: K₂CO₃ / acetone / Heating

With chloro-trimethyl-silane; boron trifluoride diethyl etherate; diisobutylaluminium hydride; potassium carbonate; triethylamine; ethanethiol; In tetrahydrofuran; dichloromethane; chloroform; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmcl.2004.08.050

Reference yield:

: 60547-92-4
4-(benzyloxy)-5-methoxy-2-nitrobenzoic acid

: 808154-82-7
[4-(4-{4-[(S)-2-(Bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-butoxy)-5-methoxy-2-nitro-phenyl]-[(S)-2-(bis-ethylsulfanyl-methyl)-4-difluoromethylene-pyrrolidin-1-yl]-methanone

Guidance literature:: Multi-step reaction with 6 steps

1: (COCl)2; DMF / tetrahydrofuran

2: Et₃N / dimethylformamide; tetrahydrofuran

3: 85 percent / DIBAL-H / CH₂Cl₂ / 0.75 h / -78 °C

4: 90 percent / TMSCl / CHCl₃ / 24 h / 20 °C

5: 80 percent / EtSH-BF₃OEt₂ / CH₂Cl₂ / 12 h / 20 °C

6: K₂CO₃ / acetone / Heating

With chloro-trimethyl-silane; oxalyl dichloride; boron trifluoride diethyl etherate; diisobutylaluminium hydride; potassium carbonate; triethylamine; N,N-dimethyl-formamide; ethanethiol; In tetrahydrofuran; dichloromethane; chloroform; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmcl.2004.08.050