5-Phenyl-6H-[1,2]oxazine-3,6-dicarboxylic acid 3-ethyl ester 6-methyl ester

Base Information

• Chemical Name: 5-Phenyl-6H-[1,2]oxazine-3,6-dicarboxylic acid 3-ethyl ester 6-methyl ester
• CAS No.: 77976-15-9
• Molecular Formula: C₁₅H₁₅NO₅
• Molecular Weight: 289.288

Synonyms:5-Phenyl-6H-[1,2]oxazine-3,6-dicarboxylic acid 3-ethyl ester 6-methyl ester

Chemical Property of 5-Phenyl-6H-[1,2]oxazine-3,6-dicarboxylic acid 3-ethyl ester 6-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Phenyl-6H-[1,2]oxazine-3,6-dicarboxylic acid 3-ethyl ester 6-methyl ester

There total 3 articles about 5-Phenyl-6H-[1,2]oxazine-3,6-dicarboxylic acid 3-ethyl ester 6-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

[(E)-Hydroxyimino]-(5-methoxy-3-phenyl-furan-2-yl)-acetic acid ethyl ester (77976-11-5) → 5-Phenyl-6H-[1,2]oxazine-3,6-dicarboxylic acid 3-ethyl ester 6-methyl ester (77976-15-9)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 0.0833333h; Heating;

DOI:10.1016/0040-4039(81)80129-3

Reference yield: 6.0%

C13H16O3S (69160-82-3) + carbethoxyformonitrile oxide (51983-62-1) → [(E)-Hydroxyimino]-(5-methoxy-3-phenyl-furan-2-yl)-acetic acid ethyl ester (77976-11-5) + 5-Phenyl-6H-[1,2]oxazine-3,6-dicarboxylic acid 3-ethyl ester 6-methyl ester (77976-15-9)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 0.5h; Ambient temperature;

DOI:10.1016/0040-4039(81)80129-3

Reference yield:

C13H16O3S (69160-82-3) → 5-Phenyl-6H-[1,2]oxazine-3,6-dicarboxylic acid 3-ethyl ester 6-methyl ester (77976-15-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 41 percent / triethylamine / tetrahydrofuran / 0.5 h / Ambient temperature

2: 78 percent / p-TsOH*H₂O / benzene / 0.08 h / Heating

With toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; benzene;

DOI:10.1016/0040-4039(81)80129-3

upstream raw materials:

C₁₃H₁₆O₃S

carbethoxyformonitrile oxide

[(E)-Hydroxyimino]-(5-methoxy-3-phenyl-furan-2-yl)-acetic acid ethyl ester

Downstream raw materials:

5-Oxo-4-phenyl-4,5-dihydro-1H-pyrrole-2,4-dicarboxylic acid 2-ethyl ester 4-methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 77976-15-9 5-Phenyl-6H-[1,2]oxazine-3,6-dicarboxylic acid 3-ethyl ester 6-methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send