<1R-(1α,2β,3α)>-1--N-(p-methoxybenzyl)hydroxycarboxamido>-3-(2-propyl)cyclopropane-2-carboxylic acid

Base Information

Chemical Name:<1R-(1α,2β,3α)>-1--N-(p-methoxybenzyl)hydroxycarboxamido>-3-(2-propyl)cyclopropane-2-carboxylic acid
CAS No.:149891-77-0
Molecular Formula:C₂₄H₂₉NO₆
Molecular Weight:427.497
Hs Code.:

<1R-(1α,2β,3α)>-1-<N-<O-(p-methoxybenzyl)>-N-(p-methoxybenzyl)hydroxycarboxamido>-3-(2-propyl)cyclopropane-2-carboxylic acid

Synonyms:<1R-(1α,2β,3α)>-1--N-(p-methoxybenzyl)hydroxycarboxamido>-3-(2-propyl)cyclopropane-2-carboxylic acid

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Chemical Property of <1R-(1α,2β,3α)>-1--N-(p-methoxybenzyl)hydroxycarboxamido>-3-(2-propyl)cyclopropane-2-carboxylic acid

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Technology Process of <1R-(1α,2β,3α)>-1--N-(p-methoxybenzyl)hydroxycarboxamido>-3-(2-propyl)cyclopropane-2-carboxylic acid

There total 11 articles about <1R-(1α,2β,3α)>-1--N-(p-methoxybenzyl)hydroxycarboxamido>-3-(2-propyl)cyclopropane-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 149953-08-2
<1R-(1α,2β,3α)>-1--N-(p-methoxybenzyl)hydroxycarboxamido>-3-(2-propyl)cyclopropane-2-carboxaldehyde

: 149891-77-0
<1R-(1α,2β,3α)>-1--N-(p-methoxybenzyl)hydroxycarboxamido>-3-(2-propyl)cyclopropane-2-carboxylic acid

Guidance literature:: With jones reagent; In acetone; at 0 - 5 ℃; for 2h;
DOI:10.1016/S0040-4020(01)90212-1

Reference yield:

: 82290-65-1
(Z)-4-methylpent-2-en-1-ol

: 149891-77-0
<1R-(1α,2β,3α)>-1--N-(p-methoxybenzyl)hydroxycarboxamido>-3-(2-propyl)cyclopropane-2-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 76 percent / N,N-dimethylaniline, Et₃N / CH₂Cl₂ / 1) 0 deg C, 15 min, 2) r.t., 30 min

2: 85 percent / Rh₂<-CH₂-CH₂-CH(CO₂Me)-N=CO->4 / CH₂Cl₂ / Heating

3: 1) Me₃Al / 1) hexane, ClCH₂CH₂Cl, r.t., 1 h, 2) ClCH₂CH₂Cl, 83 deg C, 4 h

4: 87 percent / pyridinium chlorochromate / CH₂Cl₂ / 12 h / Ambient temperature

5: K₂CO₃ / methanol / 12 h / Ambient temperature

6: 85 percent / 8 N Jones reagent / acetone / 2 h / 0 - 5 °C

With jones reagent; trimethylaluminum; potassium carbonate; N,N-dimethyl-aniline; triethylamine; pyridinium chlorochromate; Rh2<-CH2-CH2-CH(CO2Me)-N=CO->4; In methanol; dichloromethane; acetone;
DOI:10.1016/S0040-4020(01)90212-1

Reference yield:

: 149859-29-0
4-methyl-2(Z)-pentenyl diazoacetate

: 149891-77-0
<1R-(1α,2β,3α)>-1--N-(p-methoxybenzyl)hydroxycarboxamido>-3-(2-propyl)cyclopropane-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / Rh₂<-CH₂-CH₂-CH(CO₂Me)-N=CO->4 / CH₂Cl₂ / Heating

2: 1) Me₃Al / 1) hexane, ClCH₂CH₂Cl, r.t., 1 h, 2) ClCH₂CH₂Cl, 83 deg C, 4 h

3: 87 percent / pyridinium chlorochromate / CH₂Cl₂ / 12 h / Ambient temperature

4: K₂CO₃ / methanol / 12 h / Ambient temperature

5: 85 percent / 8 N Jones reagent / acetone / 2 h / 0 - 5 °C

With jones reagent; trimethylaluminum; potassium carbonate; pyridinium chlorochromate; Rh2<-CH2-CH2-CH(CO2Me)-N=CO->4; In methanol; dichloromethane; acetone;
DOI:10.1016/S0040-4020(01)90212-1