1-(2-Azido-2-deoxyarabinofuranosyl)thymine

Base Information

Chemical Name:1-(2-Azido-2-deoxyarabinofuranosyl)thymine
CAS No.:131232-94-5
Molecular Formula:C₁₀H₁₃N₅O₅
Molecular Weight:283.244
Hs Code.:
DSSTox Substance ID:DTXSID80156973
Wikidata:Q83025097
Mol file:131232-94-5.mol

Synonyms:1-(2-azido-2-deoxy-beta-D-arabinofuranosyl)thymine;1-(2-azido-2-deoxyarabinofuranosyl)thymine;1-ADAT

Suppliers and Price of 1-(2-Azido-2-deoxyarabinofuranosyl)thymine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 1-(2-Azido-2-deoxyarabinofuranosyl)thymine

Chemical Property:

Melting Point:172.5-174 °C(Solv: ethanol (64-17-5); water (7732-18-5))
Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：154.56000
Density:g/cm³
LogP:-1.36044
XLogP3:-0.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:283.09166853
Heavy Atom Count:20
Complexity:514

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)N=[N+]=[N-]
Isomeric SMILES:CC1=CN(C(=O)NC1=O)[C@H]2[C@H]([C@@H]([C@H](O2)CO)O)N=[N+]=[N-]

Technology Process of 1-(2-Azido-2-deoxyarabinofuranosyl)thymine

There total 4 articles about 1-(2-Azido-2-deoxyarabinofuranosyl)thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 131132-32-6
1-(2-azido-2-deoxy-3,5-O-TIPDS-β-D-arabinofuranosyl)thymine

: 131232-94-5
1-(2-azido-2-deoxy-β-D-arabinofuranosyl)thymine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 2h; Ambient temperature;
DOI:10.1021/jm00107a018

Reference yield:

: 131132-30-4
N³-benzoyl-3′,5′-O-(1,1,3,3-tetraisopropyl disiloxane-1,3-diyl)5-methyluridine

: 131232-94-5
1-(2-azido-2-deoxy-β-D-arabinofuranosyl)thymine

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / diethyl azodicarboxylate, triphenyl phosphorazidate, triphenylphosphine / tetrahydrofuran / 4 h / Ambient temperature

2: 90 percent / concd. NH₄OH / methanol / 2 h / Ambient temperature

3: 100 percent / tetrabutylammonium fluoride (TBAF) / tetrahydrofuran / 2 h / Ambient temperature

With ammonium hydroxide; diphenylphosphoranyl azide; tetrabutyl ammonium fluoride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol;
DOI:10.1021/jm00107a018

Reference yield:

: 131132-31-5
N³-benzoyl-1-(2-azido-2-deoxy-3,5-O-TIPDS-β-D-arabinofuranosyl)thymine

: 131232-94-5
1-(2-azido-2-deoxy-β-D-arabinofuranosyl)thymine

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / concd. NH₄OH / methanol / 2 h / Ambient temperature

2: 100 percent / tetrabutylammonium fluoride (TBAF) / tetrahydrofuran / 2 h / Ambient temperature

With ammonium hydroxide; tetrabutyl ammonium fluoride; In tetrahydrofuran; methanol;
DOI:10.1021/jm00107a018