tert-butyl (S)-(1-oxo-3-phenyl-1-((5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)amino)propan-2-yl)(thiazol-5-ylmethyl)carbamate

Base Information

• Chemical Name: tert-butyl (S)-(1-oxo-3-phenyl-1-((5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)amino)propan-2-yl)(thiazol-5-ylmethyl)carbamate
• CAS No.: 1442476-83-6
• Molecular Formula: C₂₅H₂₇N₇O₃S
• Molecular Weight: 505.6
• Mol file: 1442476-83-6.mol

Synonyms:tert-butyl (S)-(1-oxo-3-phenyl-1-((5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)amino)propan-2-yl)(thiazol-5-ylmethyl)carbamate

Chemical Property of tert-butyl (S)-(1-oxo-3-phenyl-1-((5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)amino)propan-2-yl)(thiazol-5-ylmethyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (S)-(1-oxo-3-phenyl-1-((5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)amino)propan-2-yl)(thiazol-5-ylmethyl)carbamate

There total 3 articles about tert-butyl (S)-(1-oxo-3-phenyl-1-((5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)amino)propan-2-yl)(thiazol-5-ylmethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (S)-(1-fluoro-1-oxo-3-phenylpropan-2-yl)(thiazol-5-ylmethyl)carbamate (1442476-80-3) + 3-amino-5-(4-pyridyl)-1,2,4-triazole (3652-17-3) → tert-butyl (S)-(1-oxo-3-phenyl-1-((5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)amino)propan-2-yl)(thiazol-5-ylmethyl)carbamate (1442476-83-6)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 45 ℃; Inert atmosphere;

DOI:10.1021/ml4000854

Reference yield:

(S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester (51987-73-6) → tert-butyl (S)-(1-oxo-3-phenyl-1-((5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)amino)propan-2-yl)(thiazol-5-ylmethyl)carbamate (1442476-83-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0 °C / Inert atmosphere

1.2: 2 h / 0 - 20 °C / Inert atmosphere

2.1: lithium hydroxide / water; 1,4-dioxane / 0.5 h / 20 °C

3.1: trifluoro-[1,3,5]triazine; pyridine / dichloromethane / 1 h / -20 - -10 °C

4.1: triethylamine / N,N-dimethyl-formamide / 45 °C / Inert atmosphere

With pyridine; trifluoro-[1,3,5]triazine; sodium hydride; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/ml4000854

Reference yield:

(S)-2-((tert-butoxycarbonyl)(thiazol-5-ylmethyl)amino)-3-phenylpropanoic acid (1442476-79-0) → tert-butyl (S)-(1-oxo-3-phenyl-1-((5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)amino)propan-2-yl)(thiazol-5-ylmethyl)carbamate (1442476-83-6)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoro-[1,3,5]triazine; pyridine / dichloromethane / 1 h / -20 - -10 °C

2: triethylamine / N,N-dimethyl-formamide / 45 °C / Inert atmosphere

With pyridine; trifluoro-[1,3,5]triazine; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ml4000854

upstream raw materials:

(S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester

(S)-2-((tert-butoxycarbonyl)(thiazol-5-ylmethyl)amino)-3-phenylpropanoic acid

tert-butyl (S)-(1-fluoro-1-oxo-3-phenylpropan-2-yl)(thiazol-5-ylmethyl)carbamate

3-amino-5-(4-pyridyl)-1,2,4-triazole

Downstream raw materials:

(S)-3-phenyl-N-(5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)-2-((thiazol-5-ylmethyl)amino)propanamide