(2S)-4-benzyl-1-(4-bromo-3-methylphenyl)-2-isobutylpiperazine

Base Information

Chemical Name:(2S)-4-benzyl-1-(4-bromo-3-methylphenyl)-2-isobutylpiperazine
CAS No.:1018829-32-7
Molecular Formula:C₂₂H₂₉BrN₂
Molecular Weight:401.39
Hs Code.:

Synonyms:(2S)-4-benzyl-1-(4-bromo-3-methylphenyl)-2-isobutylpiperazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-4-benzyl-1-(4-bromo-3-methylphenyl)-2-isobutylpiperazine

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Technology Process of (2S)-4-benzyl-1-(4-bromo-3-methylphenyl)-2-isobutylpiperazine

There total 1 articles about (2S)-4-benzyl-1-(4-bromo-3-methylphenyl)-2-isobutylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 444892-03-9,928025-44-9,928025-43-8
(3S)-1-benzyl-3-isobutylpiperazine

: 202865-85-8
1-bromo-4-iodo-2-methylbenzene

: 1018829-32-7
(2S)-4-benzyl-1-(4-bromo-3-methylphenyl)-2-isobutylpiperazine

Guidance literature:: With copper(I) bromide dimethylsulfide complex; caesium carbonate; 1,1'-bi-2-naphthol; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1021/ol8002749

Reference yield: 72.0%

: 1006706-60-0,198973-94-3
C₁₈H₂₂N₂

: 1018829-32-7
(2S)-4-benzyl-1-(4-bromo-3-methylphenyl)-2-isobutylpiperazine

: 1018829-36-1
(2S)-1,2-dibenzyl-4-(4-((2S)-4-benzyl-2-isobutylpiperazin-1-yl)-2-methylphenyl)piperazine

Guidance literature:: With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In toluene; at 120 - 125 ℃; for 8h; Inert atmosphere;
DOI:10.1021/ol8002749

Reference yield: 70.0%

: 1018829-30-5,78551-90-3
C₁₅H₂₄N₂

: 1018829-32-7
(2S)-4-benzyl-1-(4-bromo-3-methylphenyl)-2-isobutylpiperazine

: 1018829-35-0
(2S)-1-benzyl-4-(4-((2S)-4-benzyl-2-isobutylpiperazin-1-yl)-2-methylphenyl)-2-isobutylpiperazine

Guidance literature:: With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In toluene; at 120 - 125 ℃; for 8h; Inert atmosphere;
DOI:10.1021/ol8002749