(2S,3R,4S)-2-N-benzylhydroxylamine-4-tert-butoxycarbonylamino-1,5-dicyclohexyl-4N,3O-isopropylidene-3-pentanol

Base Information

Chemical Name:(2S,3R,4S)-2-N-benzylhydroxylamine-4-tert-butoxycarbonylamino-1,5-dicyclohexyl-4N,3O-isopropylidene-3-pentanol
CAS No.:219586-57-9
Molecular Formula:C₃₂H₅₂N₂O₄
Molecular Weight:528.776
Hs Code.:

Synonyms:(2S,3R,4S)-2-N-benzylhydroxylamine-4-tert-butoxycarbonylamino-1,5-dicyclohexyl-4N,3O-isopropylidene-3-pentanol

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Chemical Property of (2S,3R,4S)-2-N-benzylhydroxylamine-4-tert-butoxycarbonylamino-1,5-dicyclohexyl-4N,3O-isopropylidene-3-pentanol

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Technology Process of (2S,3R,4S)-2-N-benzylhydroxylamine-4-tert-butoxycarbonylamino-1,5-dicyclohexyl-4N,3O-isopropylidene-3-pentanol

There total 1 articles about (2S,3R,4S)-2-N-benzylhydroxylamine-4-tert-butoxycarbonylamino-1,5-dicyclohexyl-4N,3O-isopropylidene-3-pentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35166-78-0
cyclohexylmethyl magnesium bromide

: 219586-51-3
(Z)-N-<(4S,5R)-3-tert-butoxycarbonyl-4-cyclohexylmethyl-2,2-dimethyl-5-methylenyl-1,3-oxazolidinyl>benzylamine N-oxide

: 219586-57-9
(2S,3R,4S)-2-N-benzylhydroxylamine-4-tert-butoxycarbonylamino-1,5-dicyclohexyl-4N,3O-isopropylidene-3-pentanol

: 219586-56-8
(2R,3R,4S)-2-N-benzylhydroxylamine-4-tert-butoxycarbonylamino-1,5-dicyclohexyl-4N,3O-isopropylidene-3-pentanol

Guidance literature:: In tetrahydrofuran; diethyl ether; at -78 ℃; for 3h; Product distribution; effect of addition of Et₂AlCl; other solvent;
DOI:10.1021/jo980980u

Reference yield:

: 219586-57-9
(2S,3R,4S)-2-N-benzylhydroxylamine-4-tert-butoxycarbonylamino-1,5-dicyclohexyl-4N,3O-isopropylidene-3-pentanol

: (4S,5S)-5-((S)-1-Amino-2-cyclohexyl-ethyl)-4-cyclohexylmethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium dihydroxide; In ethanol; acetic acid; for 18h; under 2280 Torr; Ambient temperature;
DOI:10.1021/jo980980u

Reference yield:

: 219586-57-9
(2S,3R,4S)-2-N-benzylhydroxylamine-4-tert-butoxycarbonylamino-1,5-dicyclohexyl-4N,3O-isopropylidene-3-pentanol

: (2S,4S)-2,4-diamino-1,5-dicyclohexyl-3-pentanol

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd(OH)2 / acetic acid; ethanol / 18 h / 2280 Torr / Ambient temperature

2: HCl / H₂O / 3 h / 90 °C

With hydrogenchloride; hydrogen; palladium dihydroxide; In ethanol; water; acetic acid;
DOI:10.1021/jo980980u