(S)-(-)-α-(2-hydroxy-3-methoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanone

Base Information

Chemical Name:(S)-(-)-α-(2-hydroxy-3-methoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanone
CAS No.:175553-30-7
Molecular Formula:C₂₁H₂₆FNO₃
Molecular Weight:359.441
Hs Code.:

Synonyms:(S)-(-)-α-(2-hydroxy-3-methoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanone

Suppliers and Price of (S)-(-)-α-(2-hydroxy-3-methoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (S)-(-)-α-(2-hydroxy-3-methoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanone

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of (S)-(-)-α-(2-hydroxy-3-methoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanone

There total 4 articles about (S)-(-)-α-(2-hydroxy-3-methoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 175673-57-1
(-)-MDL 100907

: 175553-30-7
(S)-(-)-α-(2-hydroxy-3-methoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanone

Guidance literature:: With L-Selectride; In tetrahydrofuran; at 67 ℃; for 24h;
DOI:10.1002/(SICI)1099-1344(199910)42:10<949::AID-JLCR253>3.0.CO;2-S

Reference yield:

: 139290-69-0
(2,3-dimethoxy-phenyl)-{1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-methanol

: 175553-30-7
(S)-(-)-α-(2-hydroxy-3-methoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanone

Guidance literature:: Multi-step reaction with 3 steps

1: DCC; DMAP / CHCl₃ / 15 h / 68 °C

2: K₂CO₃; H₂O / 21 h / 22 °C

3: L-selectride / tetrahydrofuran / 24 h / 67 °C

With dmap; water; L-Selectride; potassium carbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; chloroform; 1: Esterification / 2: Hydrolysis / 3: Reduction;
DOI:10.1002/(SICI)1099-1344(199910)42:10<949::AID-JLCR253>3.0.CO;2-S

Reference yield:

: 139290-76-9
(S,S)-(+)-α-[(2,3-dimethoxyphenyl)-[1-[2-(4-fluorophenyl)ethyl]-4-piperidinyl]methyl]-α-methoxybenzene acetate

: 175553-30-7
(S)-(-)-α-(2-hydroxy-3-methoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanone

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃; H₂O / 21 h / 22 °C

2: L-selectride / tetrahydrofuran / 24 h / 67 °C

With water; L-Selectride; potassium carbonate; In tetrahydrofuran; 1: Hydrolysis / 2: Reduction;
DOI:10.1002/(SICI)1099-1344(199910)42:10<949::AID-JLCR253>3.0.CO;2-S