3-({1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-4-piperidinyl}amino)-4-nitrobenzonitrile

Base Information

Chemical Name:3-({1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-4-piperidinyl}amino)-4-nitrobenzonitrile
CAS No.:950772-84-6
Molecular Formula:C₂₁H₃₀N₄O₃
Molecular Weight:386.494
Hs Code.:

Synonyms:3-({1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-4-piperidinyl}amino)-4-nitrobenzonitrile

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Chemical Property of 3-({1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-4-piperidinyl}amino)-4-nitrobenzonitrile

Chemical Property:

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Technology Process of 3-({1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-4-piperidinyl}amino)-4-nitrobenzonitrile

There total 9 articles about 3-({1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-4-piperidinyl}amino)-4-nitrobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 218632-01-0
3-fluoro-4-nitrobenzonitrile

: 1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-4-piperidinamine dihydrochloride

: 950772-84-6
3-({1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-4-piperidinyl}amino)-4-nitrobenzonitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 110 ℃; for 0.333333h; Microwave reactor;

Reference yield:

: 3612-18-8
N-ethyl-4-piperidone

: 950772-84-6
3-({1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-4-piperidinyl}amino)-4-nitrobenzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: acetone / 3 h / 0 - 30 °C

2: potassium carbonate / ethanol; water / 2 h / 20 - 80 °C

3: ammonia; hydrogen / palladium 10% on activated carbon / methanol / 20 °C / 2585.81 Torr

4: hydrogenchloride / methanol; diethyl ether / 0.17 h

5: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.33 h / 110 °C / Microwave reactor

With hydrogenchloride; ammonia; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; diethyl ether; ethanol; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: trans-4-(ethyloxy)-1-methylcyclohexanecarboxylic acid

: 950772-84-6
3-({1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-4-piperidinyl}amino)-4-nitrobenzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: diphenyl phosphoryl azide; triethylamine / toluene / 1 h / 20 - 85 °C

2: hydrogenchloride / tetrahydrofuran; water / 20 °C

3: potassium carbonate / ethanol; water / 2 h / 20 - 80 °C

4: ammonia; hydrogen / palladium 10% on activated carbon / methanol / 20 °C / 2585.81 Torr

5: hydrogenchloride / methanol; diethyl ether / 0.17 h

6: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.33 h / 110 °C / Microwave reactor

With hydrogenchloride; diphenyl phosphoryl azide; ammonia; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; diethyl ether; ethanol; water; N,N-dimethyl-formamide; toluene;