methyl 1-(4-fluorobenzyl)-3-[(2-methoxyethoxy)methyl]-1H-pyrrolo[2,3-c]pyridine-5-carboxylate

Base Information

• Chemical Name: methyl 1-(4-fluorobenzyl)-3-[(2-methoxyethoxy)methyl]-1H-pyrrolo[2,3-c]pyridine-5-carboxylate
• CAS No.: 868551-75-1
• Molecular Formula: C₂₀H₂₁FN₂O₄
• Molecular Weight: 372.396
• Mol file: 868551-75-1.mol

Synonyms:methyl 1-(4-fluorobenzyl)-3-[(2-methoxyethoxy)methyl]-1H-pyrrolo[2,3-c]pyridine-5-carboxylate

Chemical Property of methyl 1-(4-fluorobenzyl)-3-[(2-methoxyethoxy)methyl]-1H-pyrrolo[2,3-c]pyridine-5-carboxylate

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 1-(4-fluorobenzyl)-3-[(2-methoxyethoxy)methyl]-1H-pyrrolo[2,3-c]pyridine-5-carboxylate

There total 2 articles about methyl 1-(4-fluorobenzyl)-3-[(2-methoxyethoxy)methyl]-1H-pyrrolo[2,3-c]pyridine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C17H13ClF2N2O2 (868552-03-8) + 2-methoxy-ethanol (109-86-4,95507-80-5) → methyl 1-(4-fluorobenzyl)-3-[(2-methoxyethoxy)methyl]-1H-pyrrolo[2,3-c]pyridine-5-carboxylate (868551-75-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 40 ℃; for 24h;

Reference yield: 91.0%

methyl 3-[(dimethylamino)methyl]-1-(4-fluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate (868552-11-8) + 2-methoxy-ethanol (109-86-4,95507-80-5) → methyl 1-(4-fluorobenzyl)-3-[(2-methoxyethoxy)methyl]-1H-pyrrolo[2,3-c]pyridine-5-carboxylate (868551-75-1)

Guidance literature:

methyl 3-[(dimethylamino)methyl]-1-(4-fluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate; With chloroformic acid ethyl ester; In dichloromethane; at 20 ℃; for 0.333333h; Inert atmosphere;

2-methoxy-ethanol; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 40 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.bmcl.2010.10.022

Reference yield: 76.0%

methyl 1-(4-fluorobenzyl)-3-[(2-methoxyethoxy)methyl]-1H-pyrrolo[2,3-c]pyridine-5-carboxylate (868551-75-1) → 1-(4-fluorobenzyl)-3-[(2-methoxyethoxy)methyl]-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid (868551-76-2)

Guidance literature:

methyl 1-(4-fluorobenzyl)-3-[(2-methoxyethoxy)methyl]-1H-pyrrolo[2,3-c]pyridine-5-carboxylate; With lithium hydroxide; water; In tetrahydrofuran; at 40 ℃; for 3h;

With hydrogenchloride; In water;

upstream raw materials:

C₁₇H₁₃ClF₂N₂O₂

2-methoxy-ethanol

methyl 3-[(dimethylamino)methyl]-1-(4-fluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate

Downstream raw materials:

1-(4-fluorobenzyl)-3-[(2-methoxyethoxy)methyl]-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid