methyl 1-(4-fluorobenzyl)-3-[(2-methoxyethoxy)methyl]-1H-pyrrolo[2,3-c]pyridine-5-carboxylate

Base Information

Chemical Name:methyl 1-(4-fluorobenzyl)-3-[(2-methoxyethoxy)methyl]-1H-pyrrolo[2,3-c]pyridine-5-carboxylate
CAS No.:868551-75-1
Molecular Formula:C₂₀H₂₁FN₂O₄
Molecular Weight:372.396
Hs Code.:

Synonyms:methyl 1-(4-fluorobenzyl)-3-[(2-methoxyethoxy)methyl]-1H-pyrrolo[2,3-c]pyridine-5-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 1-(4-fluorobenzyl)-3-[(2-methoxyethoxy)methyl]-1H-pyrrolo[2,3-c]pyridine-5-carboxylate

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Purity/Quality:: 95% ^*data from raw suppliers

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Technology Process of methyl 1-(4-fluorobenzyl)-3-[(2-methoxyethoxy)methyl]-1H-pyrrolo[2,3-c]pyridine-5-carboxylate

There total 2 articles about methyl 1-(4-fluorobenzyl)-3-[(2-methoxyethoxy)methyl]-1H-pyrrolo[2,3-c]pyridine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 868552-03-8
C₁₇H₁₃ClF₂N₂O₂

: 109-86-4,95507-80-5
2-methoxy-ethanol

: 868551-75-1
methyl 1-(4-fluorobenzyl)-3-[(2-methoxyethoxy)methyl]-1H-pyrrolo[2,3-c]pyridine-5-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 40 ℃; for 24h;

Reference yield: 91.0%

: 868552-11-8
methyl 3-[(dimethylamino)methyl]-1-(4-fluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate

: 109-86-4,95507-80-5
2-methoxy-ethanol

: 868551-75-1
methyl 1-(4-fluorobenzyl)-3-[(2-methoxyethoxy)methyl]-1H-pyrrolo[2,3-c]pyridine-5-carboxylate

Guidance literature:: methyl 3-[(dimethylamino)methyl]-1-(4-fluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate; With chloroformic acid ethyl ester; In dichloromethane; at 20 ℃; for 0.333333h; Inert atmosphere;

2-methoxy-ethanol; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 40 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.bmcl.2010.10.022

Reference yield: 76.0%

: 868551-75-1
methyl 1-(4-fluorobenzyl)-3-[(2-methoxyethoxy)methyl]-1H-pyrrolo[2,3-c]pyridine-5-carboxylate

: 868551-76-2
1-(4-fluorobenzyl)-3-[(2-methoxyethoxy)methyl]-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid

Guidance literature:: methyl 1-(4-fluorobenzyl)-3-[(2-methoxyethoxy)methyl]-1H-pyrrolo[2,3-c]pyridine-5-carboxylate; With lithium hydroxide; water; In tetrahydrofuran; at 40 ℃; for 3h;

With hydrogenchloride; In water;