(7R,8S,8aR)-7-hydroxy-8-[(1R,2S)-trans-2-phenyl-1-cyclohexyloxycarbonyl]octahydroindolizine

Base Information

Chemical Name:(7R,8S,8aR)-7-hydroxy-8-[(1R,2S)-trans-2-phenyl-1-cyclohexyloxycarbonyl]octahydroindolizine
CAS No.:318268-19-8
Molecular Formula:C₂₁H₂₉NO₃
Molecular Weight:343.466
Hs Code.:

Synonyms:(7R,8S,8aR)-7-hydroxy-8-[(1R,2S)-trans-2-phenyl-1-cyclohexyloxycarbonyl]octahydroindolizine

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Chemical Property of (7R,8S,8aR)-7-hydroxy-8-[(1R,2S)-trans-2-phenyl-1-cyclohexyloxycarbonyl]octahydroindolizine

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Technology Process of (7R,8S,8aR)-7-hydroxy-8-[(1R,2S)-trans-2-phenyl-1-cyclohexyloxycarbonyl]octahydroindolizine

There total 4 articles about (7R,8S,8aR)-7-hydroxy-8-[(1R,2S)-trans-2-phenyl-1-cyclohexyloxycarbonyl]octahydroindolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 318268-12-1
(1R,2S)-trans-2-phenyl-1-cyclohexyl (E)-5-hydroxy-2-pentenoate

: 318268-19-8
(7R,8S,8aR)-7-hydroxy-8-[(1R,2S)-trans-2-phenyl-1-cyclohexyloxycarbonyl]octahydroindolizine

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / triethylamine / CH₂Cl₂ / 1.5 h / 20 °C

2: 213 mg / toluene

With triethylamine; In dichloromethane; toluene; 1: mesylation / 2: Cycloaddition;
DOI:10.1002/1099-0690(200011)2000:21<3595::AID-EJOC3595>3.0.CO;2-N

Reference yield:

: 318268-08-5
(1R,2S)-trans-2-phenyl-1-cyclohexyl (E)-5-[(tetrahydro-2H-pyran-2-yl)oxy]-2-pentenoate

: 318268-19-8
(7R,8S,8aR)-7-hydroxy-8-[(1R,2S)-trans-2-phenyl-1-cyclohexyloxycarbonyl]octahydroindolizine

Guidance literature:: Multi-step reaction with 3 steps

1: Amberlyst 15 / methanol / 6.5 h / 40 °C

2: 96 percent / triethylamine / CH₂Cl₂ / 1.5 h / 20 °C

3: 213 mg / toluene

With Amberlyst 15; triethylamine; In methanol; dichloromethane; toluene; 1: Hydrolysis / 2: mesylation / 3: Cycloaddition;
DOI:10.1002/1099-0690(200011)2000:21<3595::AID-EJOC3595>3.0.CO;2-N

Reference yield:

: Triphenyl-((1R,2S)-2-phenyl-cyclohexyloxycarbonylmethyl)-phosphonium; bromide

: 318268-19-8
(7R,8S,8aR)-7-hydroxy-8-[(1R,2S)-trans-2-phenyl-1-cyclohexyloxycarbonyl]octahydroindolizine

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / triethylamine / CH₂Cl₂

2: Amberlyst 15 / methanol / 6.5 h / 40 °C

3: 96 percent / triethylamine / CH₂Cl₂ / 1.5 h / 20 °C

4: 213 mg / toluene

With Amberlyst 15; triethylamine; In methanol; dichloromethane; toluene; 1: Condensation / 2: Hydrolysis / 3: mesylation / 4: Cycloaddition;
DOI:10.1002/1099-0690(200011)2000:21<3595::AID-EJOC3595>3.0.CO;2-N