3-benzoyl-4-oxo-5-(3-chloropropyl)-8-(2-tetrahydropyranyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indole

Base Information

Chemical Name:3-benzoyl-4-oxo-5-(3-chloropropyl)-8-(2-tetrahydropyranyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indole
CAS No.:80063-77-0
Molecular Formula:C₂₉H₃₃ClN₂O₃
Molecular Weight:493.046
Hs Code.:

Synonyms:3-benzoyl-4-oxo-5-(3-chloropropyl)-8-(2-tetrahydropyranyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indole

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Chemical Property of 3-benzoyl-4-oxo-5-(3-chloropropyl)-8-(2-tetrahydropyranyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indole

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Technology Process of 3-benzoyl-4-oxo-5-(3-chloropropyl)-8-(2-tetrahydropyranyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indole

There total 13 articles about 3-benzoyl-4-oxo-5-(3-chloropropyl)-8-(2-tetrahydropyranyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 6940-76-7
1-iodo-3-chloro-propane

: 80053-46-9
3-benzoyl-4-oxo-8-(2-tetrahydropyranyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indole

: 80063-77-0
3-benzoyl-4-oxo-5-(3-chloropropyl)-8-(2-tetrahydropyranyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indole

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1021/ja00413a049

Reference yield:

: 89650-66-8
6-oxo-6,7,8,9-tetrahydro-pyrido(1,2-a)indole-10-propionic-acid

: 80063-77-0
3-benzoyl-4-oxo-5-(3-chloropropyl)-8-(2-tetrahydropyranyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indole

Guidance literature:: Multi-step reaction with 5 steps

2: 80 percent / methanol / 18 h / Irradiation

3: 77 percent / Et₃N / tetrahydrofuran / Ambient temperature

4: 89 percent / camforsulfonic acid / CH₂Cl₂ / 8 h / Ambient temperature

5: 71 percent / lithium diisopropylamide / tetrahydrofuran; hexamethylphosphoric acid triamide

With camphor-10-sulfonic acid; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;
DOI:10.1021/ja00413a049

Reference yield:

: 73608-98-7
6,7,9,10,11,12-Hexahydro-5H-7,12-diaza-cyclonona[a]inden-8-one

: 80063-77-0
3-benzoyl-4-oxo-5-(3-chloropropyl)-8-(2-tetrahydropyranyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indole

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / Et₃N / tetrahydrofuran / Ambient temperature

2: 89 percent / camforsulfonic acid / CH₂Cl₂ / 8 h / Ambient temperature

3: 71 percent / lithium diisopropylamide / tetrahydrofuran; hexamethylphosphoric acid triamide

With camphor-10-sulfonic acid; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;
DOI:10.1021/ja00413a049