methyl 2-(2-(indolin-1-yl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate

Base Information

Chemical Name:methyl 2-(2-(indolin-1-yl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate
CAS No.:1265397-10-1
Molecular Formula:C₂₆H₂₉N₃O₂
Molecular Weight:415.535
Hs Code.:

Synonyms:methyl 2-(2-(indolin-1-yl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate

Suppliers and Price of methyl 2-(2-(indolin-1-yl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 2-(2-(indolin-1-yl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 2-(2-(indolin-1-yl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate

There total 13 articles about methyl 2-(2-(indolin-1-yl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 496-15-1
1-indoline

: 1265393-37-0
methyl 2-(2-chloro-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate

: 1265397-10-1
methyl 2-(2-(indolin-1-yl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; sodium iodide; In 1-methyl-pyrrolidin-2-one; acetonitrile; at 160 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 615-83-8
2-bromo-pentanoic acid ethyl ester

: 1265397-10-1
methyl 2-(2-(indolin-1-yl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere

2.1: sodium methylate / methanol / 21 h / 80 °C

2.2: 0.5 h / 20 °C

3.1: water; chloroacetic acid / 20 h / Reflux

4.1: thionyl chloride / 48 h / 0 °C / Reflux

5.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 115 °C

6.1: N-ethyl-N,N-diisopropylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 2 h / 90 °C

7.1: N-ethyl-N,N-diisopropylamine; sodium iodide / 1-methyl-pyrrolidin-2-one; acetonitrile / 0.5 h / 160 °C / Microwave irradiation

With thionyl chloride; water; sodium methylate; potassium carbonate; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; chloroacetic acid; sodium iodide; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1-methyl-pyrrolidin-2-one; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 162498-52-4
(2,4-dichloro-6-methylpyrimidin-5-yl)acetic acid methyl ester

: 1265397-10-1
methyl 2-(2-(indolin-1-yl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 3.5 h / Reflux

2.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 0.25 h / -78 °C

2.2: 3 h / -15 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine; sodium iodide / 1-methyl-pyrrolidin-2-one; acetonitrile / 0.5 h / 160 °C / Microwave irradiation

With N-ethyl-N,N-diisopropylamine; sodium iodide; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; acetonitrile;