(Z)-5-((6-(methyl(2-(pyridin-2-yl)ethyl)amino)-2-(4-(p-tolyl)piperazin-1-yl)pyrimidin-4-yl)methylene)thiazolidine-2,4-dione

Base Information

Chemical Name:(Z)-5-((6-(methyl(2-(pyridin-2-yl)ethyl)amino)-2-(4-(p-tolyl)piperazin-1-yl)pyrimidin-4-yl)methylene)thiazolidine-2,4-dione
CAS No.:1312662-76-2
Molecular Formula:C₂₇H₂₉N₇O₂S
Molecular Weight:515.639
Hs Code.:

Synonyms:(Z)-5-((6-(methyl(2-(pyridin-2-yl)ethyl)amino)-2-(4-(p-tolyl)piperazin-1-yl)pyrimidin-4-yl)methylene)thiazolidine-2,4-dione

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Chemical Property of (Z)-5-((6-(methyl(2-(pyridin-2-yl)ethyl)amino)-2-(4-(p-tolyl)piperazin-1-yl)pyrimidin-4-yl)methylene)thiazolidine-2,4-dione

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Technology Process of (Z)-5-((6-(methyl(2-(pyridin-2-yl)ethyl)amino)-2-(4-(p-tolyl)piperazin-1-yl)pyrimidin-4-yl)methylene)thiazolidine-2,4-dione

There total 6 articles about (Z)-5-((6-(methyl(2-(pyridin-2-yl)ethyl)amino)-2-(4-(p-tolyl)piperazin-1-yl)pyrimidin-4-yl)methylene)thiazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2295-31-0
thiazoline-2,4-dione

: C₂₄H₂₈N₆O

: 1312662-76-2
(Z)-5-((6-(methyl(2-(pyridin-2-yl)ethyl)amino)-2-(4-(p-tolyl)piperazin-1-yl)pyrimidin-4-yl)methylene)thiazolidine-2,4-dione

Guidance literature:: With piperidine; In ethanol; at 85 ℃; for 16h;

Reference yield:

: 5638-76-6
betahistine

: 1312662-76-2
(Z)-5-((6-(methyl(2-(pyridin-2-yl)ethyl)amino)-2-(4-(p-tolyl)piperazin-1-yl)pyrimidin-4-yl)methylene)thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 0 °C

2.1: N-ethyl-N,N-diisopropylamine / ethanol / 48 h / 90 °C

3.1: diisobutylaluminium hydride / dichloromethane / -10 - 20 °C

3.2: 0.5 h

4.1: Dess-Martin periodane / dichloromethane / 0 - 20 °C

5.1: piperidine / ethanol / 16 h / 85 °C

With piperidine; diisobutylaluminium hydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 6299-85-0
2,6-dichloropyrimidine-4-carboxylic acid methyl ester

: 1312662-76-2
(Z)-5-((6-(methyl(2-(pyridin-2-yl)ethyl)amino)-2-(4-(p-tolyl)piperazin-1-yl)pyrimidin-4-yl)methylene)thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 0 °C

2.1: N-ethyl-N,N-diisopropylamine / ethanol / 48 h / 90 °C

3.1: diisobutylaluminium hydride / dichloromethane / -10 - 20 °C

3.2: 0.5 h

4.1: Dess-Martin periodane / dichloromethane / 0 - 20 °C

5.1: piperidine / ethanol / 16 h / 85 °C

With piperidine; diisobutylaluminium hydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane;