Technology Process of (R)-1-(allyloxy)-3-(3,4-bis(benzyloxy)phenyl)-1-oxopropan-2-yl (E)-3-(4-hydroxy-3-methoxyphenyl)acrylate
There total 1 articles about (R)-1-(allyloxy)-3-(3,4-bis(benzyloxy)phenyl)-1-oxopropan-2-yl (E)-3-(4-hydroxy-3-methoxyphenyl)acrylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 6 steps
1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 25 - 55 °C / Inert atmosphere
2: methanol; N,N-dimethyl-formamide / 4.5 h / 25 °C / Inert atmosphere
3: lithium hydroxide / methanol; tetrahydrofuran; water / 6 h / 0 - 45 °C / Inert atmosphere
4: potassium carbonate / N,N-dimethyl-formamide / 2 h / 25 °C / Inert atmosphere
5: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 25 °C / Inert atmosphere
6: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
With
dmap; tetrabutyl ammonium fluoride; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo4023167