(Z)-N-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)-2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxamide

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Chemical Name:(Z)-N-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)-2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxamide
CAS No.:1474049-96-1
Molecular Formula:C₂₅H₁₈N₄O₃
Molecular Weight:422.443
Hs Code.:

Synonyms:(Z)-N-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)-2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxamide

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Chemical Property of (Z)-N-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)-2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxamide

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Technology Process of (Z)-N-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)-2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxamide

There total 7 articles about (Z)-N-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)-2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1474049-96-1
(Z)-N-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)-2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxamide

Guidance literature:: With pyrrolidine; In ethanol; Reflux;

Reference yield:

: 1003-29-8,254729-95-8
2-pyrrole aldehyde

: 1621689-35-7
C₂₀H₁₅N₃O₃

: 1474049-96-1
(Z)-N-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)-2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxamide

Guidance literature:: With pyrrolidine; In ethanol; at 100 ℃; Microwave irradiation;
DOI:10.1016/j.ejmech.2014.07.033

Reference yield:

: 62-53-3
aniline

: 1474049-96-1
(Z)-N-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)-2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: N,N-dimethyl-formamide / 6 h / 20 °C / Cooling with ice

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / N,N-dimethyl-formamide / 20 °C

3: sodium hydroxide / methanol / 3 h / Reflux

4: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide; acetonitrile / 3 h / 20 °C

5: pyrrolidine / ethanol / 100 °C / Microwave irradiation

With pyrrolidine; dmap; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In methanol; ethanol; N,N-dimethyl-formamide; acetonitrile; 5: |Aldol Condensation;
DOI:10.1016/j.ejmech.2014.07.033