4-Methyl-4-phenylpiperidine

Base Information

• Chemical Name: 4-Methyl-4-phenylpiperidine
• CAS No.: 160132-91-2
• Molecular Formula: C₁₂H₁₇N
• Molecular Weight: 175.274
• European Community (EC) Number: 815-548-3
• DSSTox Substance ID: DTXSID50388527
• Nikkaji Number: J291.328C
• Wikidata: Q82183557
• Mol file: 160132-91-2.mol

Synonyms:4-methyl-4-phenylpiperidine;160132-91-2;Piperidine, 4-methyl-4-phenyl-;4-methyl-4-phenyl piperidine;SCHEMBL737635;DTXSID50388527;WMZXPOYYJULZMD-UHFFFAOYSA-N;AKOS012000672;SB41420;CS-0308347;FT-0749916;EN300-116611;F51135;Z1095369049

Chemical Property of 4-Methyl-4-phenylpiperidine

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 175.136099547
• Heavy Atom Count: 13
• Complexity: 153

Purity/Quality:

97% ^*data from raw suppliers

4-Methyl-4-phenylpiperidine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CCNCC1)C2=CC=CC=C2

Technology Process of 4-Methyl-4-phenylpiperidine

There total 4 articles about 4-Methyl-4-phenylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-benzyl-4-methyl-4-phenyl piperidine (160133-26-6) → 4-methyl-4-phenyl piperidine (160132-91-2)

Guidance literature:

Pd-C; In methanol; hydrogen;

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) → 4-methyl-4-phenyl piperidine (160132-91-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 87 percent / diethyl ether / 1.5 h / -78 °C

2: 52 percent / AlCl₃ / 24 h / Heating

3: 51 percent / HCO₂H / 10 percent Pd/C / methanol / 24 h / Ambient temperature

With aluminium trichloride; formic acid; palladium on activated charcoal; In methanol; diethyl ether;

Reference yield:

1-benzyl-4-methyl-piperidin-4-ol (3970-66-9) → 4-methyl-4-phenyl piperidine (160132-91-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / AlCl₃ / 24 h / Heating

2: 51 percent / HCO₂H / 10 percent Pd/C / methanol / 24 h / Ambient temperature

With aluminium trichloride; formic acid; palladium on activated charcoal; In methanol;

upstream raw materials:

1-benzyl-4-methyl-4-phenyl piperidine

1-phenylmethyl-4-piperidone

1-benzyl-4-methyl-piperidin-4-ol

Downstream raw materials:

1-(3-amino-propyl)-4-methyl-4-phenyl-piperidine