2-amino-5-methoxy-4-(2-(piperidin-1-yl)ethoxy)benzoic acid methyl ester

Base Information

• Chemical Name: 2-amino-5-methoxy-4-(2-(piperidin-1-yl)ethoxy)benzoic acid methyl ester
• CAS No.: 1352738-41-0
• Molecular Formula: C₁₆H₂₄N₂O₄
• Molecular Weight: 308.378
• Mol file: 1352738-41-0.mol

Synonyms:2-amino-5-methoxy-4-(2-(piperidin-1-yl)ethoxy)benzoic acid methyl ester

Chemical Property of 2-amino-5-methoxy-4-(2-(piperidin-1-yl)ethoxy)benzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-5-methoxy-4-(2-(piperidin-1-yl)ethoxy)benzoic acid methyl ester

There total 10 articles about 2-amino-5-methoxy-4-(2-(piperidin-1-yl)ethoxy)benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.3%

2-nitro-5-methoxy-4-(2-(piperidin-1-yl)ethoxy)benzoic acid methyl ester (1352738-37-4) → 2-amino-5-methoxy-4-(2-(piperidin-1-yl)ethoxy)benzoic acid methyl ester (1352738-41-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃;

Reference yield:

4-hydroxy-3-methoxybenzoic acid methyl ester (3943-74-6) → 2-amino-5-methoxy-4-(2-(piperidin-1-yl)ethoxy)benzoic acid methyl ester (1352738-41-0)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 5 h / Reflux

2: nitric acid; tin(IV) chloride / dichloromethane / 4 h / -70 - 20 °C

3: hydrogen / dichloromethane; methanol / 18 h / 20 °C

With hydrogen; nitric acid; tin(IV) chloride; potassium carbonate; In methanol; dichloromethane; acetone;

DOI:10.1016/j.ejmech.2014.04.007

Reference yield:

methyl 3-methoxy-4-piperidinoethoxybenzoate (1609458-47-0) → 2-amino-5-methoxy-4-(2-(piperidin-1-yl)ethoxy)benzoic acid methyl ester (1352738-41-0)

Guidance literature:

Multi-step reaction with 2 steps

1: nitric acid; tin(IV) chloride / dichloromethane / 4 h / -70 - 20 °C

2: hydrogen / dichloromethane; methanol / 18 h / 20 °C

With hydrogen; nitric acid; tin(IV) chloride; In methanol; dichloromethane;

DOI:10.1016/j.ejmech.2014.04.007

upstream raw materials:

methyl 3-methoxy-4-piperidinoethoxybenzoate

4-hydroxy-3-methoxybenzoic acid methyl ester

2-(piperidin-4-yl)ethyl chloride

2-nitro-5-methoxy-4-(2-(piperidin-1-yl)ethoxy)benzoic acid methyl ester

Downstream raw materials:

N-(3-bromophenyl)-N'-{4-[(6-methoxy-7-piperidinoethoxyquinazolin-4-yl)oxy]phenyl}urea hydrochloride

N-(3-bromophenyl)-N'-{3-methyl-4-[(6-methoxy-7-piperidinoethoxyquinazolin-4-yl)oxy]phenyl}urea

N-(3-bromo-phenyl)-N'-{3-chloro-4-[(6-methoxy-7-piperidinoethoxyquinazolin-4-yl)oxy]phenyl}urea