11,17-Dihydroxy-6-methyl-17-(1-propynyl)androsta-1,4,6-triene-3-one

Base Information

Chemical Name:11,17-Dihydroxy-6-methyl-17-(1-propynyl)androsta-1,4,6-triene-3-one
CAS No.:74915-64-3
Molecular Formula:C₂₃H₂₈O₃
Molecular Weight:352.474
Hs Code.:
UNII:VH397CN9SV
DSSTox Substance ID:DTXSID101027141
Nikkaji Number:J397.580K
Wikipedia:RU-28362
Wikidata:Q7277962

Synonyms:11,17-dihydroxy-6-methyl-17-(1-propynyl)androsta-1,4,6-triene-3-one;RU 28362;RU 362;RU-28362;RU-362

Suppliers and Price of 11,17-Dihydroxy-6-methyl-17-(1-propynyl)androsta-1,4,6-triene-3-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(11BETA,17BETA)-11,17-DIHYDROXY-6-METHYL-17-(1-PROPYNYL)-ANDROSTA-1,4,6-TRIEN-3-ONE 95.00%
5MG
$ 497.12

Total 1 raw suppliers

Chemical Property of 11,17-Dihydroxy-6-methyl-17-(1-propynyl)androsta-1,4,6-triene-3-one

Chemical Property:

Vapor Pressure:1.35E-13mmHg at 25°C
Boiling Point:533.2°C at 760 mmHg
Flash Point:290.4°C
PSA：57.53000
Density:1.21g/cm³
LogP:3.18560
Storage Temp.:2-8°C
Solubility.:DMSO: 33?mg/mL, soluble
XLogP3:2.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:352.20384475
Heavy Atom Count:26
Complexity:834

Purity/Quality:

99% ^*data from raw suppliers

(11BETA,17BETA)-11,17-DIHYDROXY-6-METHYL-17-(1-PROPYNYL)-ANDROSTA-1,4,6-TRIEN-3-ONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC#CC1(CCC2C1(CC(C3C2C=C(C4=CC(=O)C=CC34C)C)O)C)O
Isomeric SMILES:CC#C[C@@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2C=C(C4=CC(=O)C=C[C@]34C)C)O)C)O

Technology Process of 11,17-Dihydroxy-6-methyl-17-(1-propynyl)androsta-1,4,6-triene-3-one

There total 3 articles about 11,17-Dihydroxy-6-methyl-17-(1-propynyl)androsta-1,4,6-triene-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74915-67-6
11β-hydroxy-6α-methyl-4-androstene-3,17-dione

: 74915-64-3
11β,17β-dihydroxy-6,21-dimethyl-17α-pregna-1,4,6-trien-20-yn-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / p-toluenesulfonic acid monohydrate / ethanol / 60 °C

2: 2.) DDQ / 1.) THF, 45 min, r.t., 2.) benzene, 30 min

With toluene-4-sulfonic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In ethanol;
DOI:10.1016/0039-128X(81)90084-2

Reference yield:

: 81176-90-1
11β,17β,21-trihydroxy-6α-methyl-4-pregnene-3,20-dione

: 74915-64-3
11β,17β-dihydroxy-6,21-dimethyl-17α-pregna-1,4,6-trien-20-yn-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / sodium bismuthate / aq. acetic acid / 60 h / Ambient temperature

2: 81 percent / p-toluenesulfonic acid monohydrate / ethanol / 60 °C

3: 2.) DDQ / 1.) THF, 45 min, r.t., 2.) benzene, 30 min

With sodium bismuthate; toluene-4-sulfonic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In ethanol; acetic acid;
DOI:10.1016/0039-128X(81)90084-2

Reference yield:

: 16466-97-0,13254-27-8
1-propynylmagnesium bromide

: 74915-66-5
3-ethoxy-11β-hydroxy-6-methyl-3,5-androstadien-17-one

: 74915-64-3
11β,17β-dihydroxy-6,21-dimethyl-17α-pregna-1,4,6-trien-20-yn-3-one

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; Yield given. Multistep reaction; 1.) THF, 45 min, r.t., 2.) benzene, 30 min;
DOI:10.1016/0039-128X(81)90084-2