Gomisin S

Base Information

• Chemical Name: Gomisin S
• CAS No.: 119239-49-5
• Molecular Formula: C₂₃H₃₀O₇
• Molecular Weight: 418.487
• Mol file: 119239-49-5.mol

Synonyms:Dibenzo[a,c]cyclooctene-3,8-diol,5,6,7,8-tetrahydro-1,2,10,11,12-pentamethoxy-6,7-dimethyl-, stereoisomer;Gomisin S

Chemical Property of Gomisin S

Chemical Property:

• Boiling Point: 594.3±50.0 °C(Predicted)
• PKA: 9.17±0.70(Predicted)
• PSA: 86.61000
• Density: 1.172±0.06 g/cm3(Predicted)
• LogP: 3.96390

Purity/Quality:

≥98% ^*data from raw suppliers

GomisinS ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Gomisin S

There total 4 articles about Gomisin S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Benzoylgomisin U (130783-33-4) → Gomisin U (119139-58-1,119239-49-5,122407-78-7,135095-46-4)

Guidance literature:

With potassium hydroxide; In ethanol; at 65 ℃; for 3h; Yield given;

DOI:10.1016/0031-9422(91)85290-G

Reference yield:

kadsulignan A (122350-74-7) → (6R,7R,8R)-2,10,11,12-Tetramethoxy-6,7-dimethyl-5,6,7,8-tetrahydro-dibenzo[a,c]cyclooctene-3,8-diol (122364-67-4) + (6R,7R,8R)-1,2,10,11,12-Pentamethoxy-6,7-dimethyl-5,6,7,8-tetrahydro-dibenzo[a,c]cyclooctene-3,8-diol (119139-58-1,119239-49-5,122407-78-7,135095-46-4)

Guidance literature:

With dichloroaluminum hydride; In diethyl ether; at 0 ℃; for 0.0833333h;

Reference yield:

Acetic acid (5R,6S,7S)-10-acetoxy-1,2,3,11,12-pentamethoxy-6,7-dimethyl-5,6,7,8-tetrahydro-dibenzo[a,c]cycloocten-5-yl ester (119139-57-0,119239-47-3) → (6S,7S,8R)-1,2,10,11,12-Pentamethoxy-6,7-dimethyl-5,6,7,8-tetrahydro-dibenzo[a,c]cyclooctene-3,8-diol (119139-58-1,119239-49-5,122407-78-7,135095-46-4)

Guidance literature:

With potassium hydroxide; at 60 ℃; for 3h;

upstream raw materials:

Benzoylgomisin U

Acetic acid (5R,6S,7S)-10-acetoxy-1,2,3,11,12-pentamethoxy-6,7-dimethyl-5,6,7,8-tetrahydro-dibenzo[a,c]cycloocten-5-yl ester

gomisin K₁ acetate

kadsulignan A

Refernces

• 1、 Liu, Jia-Sen,Li, Liang,Yu, Han-Gang. "Kadsulignan A and B, two nonel lignans from Kadsura coccinea". . p. 682 - 684. Retrieved 2007/10/02.