(R)-2-phenylpyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

Base Information

Chemical Name:(R)-2-phenylpyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester
CAS No.:1364782-40-0
Molecular Formula:C₁₇H₂₃NO₄
Molecular Weight:305.374
Hs Code.:

Synonyms:(R)-2-phenylpyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

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Chemical Property of (R)-2-phenylpyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

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Technology Process of (R)-2-phenylpyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

There total 2 articles about (R)-2-phenylpyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 79-22-1
methyl chloroformate

: 174311-02-5
2-phenylpyrrolidine-1-carboxylic acid tert-butyl ester

: 1364782-40-0
(R)-2-phenylpyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

Guidance literature:: 2-phenylpyrrolidine-1-carboxylic acid tert-butyl ester; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

methyl chloroformate; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h; optical yield given as %ee; Inert atmosphere;
DOI:10.1021/ja211398b

Reference yield:

: 79-22-1
methyl chloroformate

: 174311-02-5
2-phenylpyrrolidine-1-carboxylic acid tert-butyl ester

: 1364782-35-3
(S)-2-phenylpyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

: 1364782-40-0
(R)-2-phenylpyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

Guidance literature:: 2-phenylpyrrolidine-1-carboxylic acid tert-butyl ester; With n-butyllithium; In tetrahydrofuran; hexane; at -50 ℃; for 0.0833333h; Inert atmosphere;

methyl chloroformate; In tetrahydrofuran; hexane; at -50 ℃; for 0.166667h; optical yield given as %ee; Inert atmosphere;
DOI:10.1021/ja211398b