(S)-4-amino-2,6-dimethylhept-1-en-3-one trifluoroacetate

Base Information

Chemical Name:(S)-4-amino-2,6-dimethylhept-1-en-3-one trifluoroacetate
CAS No.:1619233-32-7
Molecular Formula:C₂HF₃O₂*C₉H₁₇NO
Molecular Weight:269.264
Hs Code.:

Synonyms:(S)-4-amino-2,6-dimethylhept-1-en-3-one trifluoroacetate

Suppliers and Price of (S)-4-amino-2,6-dimethylhept-1-en-3-one trifluoroacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(4S)-4-Amino-2,6-dimethyl-1-hepten-3-one2,2,2-Trifluoroacetate
50mg
$ 165.00

Total 2 raw suppliers

Chemical Property of (S)-4-amino-2,6-dimethylhept-1-en-3-one trifluoroacetate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

(4S)-4-Amino-2,6-dimethyl-1-hepten-3-one2,2,2-Trifluoroacetate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (4S)-4-Amino-2,6-dimethyl-1-hepten-3-one 2,2,2-Trifluoroacetate is a reagent used for carbonyls and epoxides as dual electrophiles in peptide-based proteasome inhibitors. This is also an impurity of carfilzomib (C183460), which is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.

Technology Process of (S)-4-amino-2,6-dimethylhept-1-en-3-one trifluoroacetate

There total 3 articles about (S)-4-amino-2,6-dimethylhept-1-en-3-one trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 76-05-1
trifluoroacetic acid

: 247068-81-1
tert-butyl [(1S)-3-methyl-1-(2-methylpropyl)-2-oxobut-3-en-1-yl]carbamate

: 1619233-32-7
(S)-4-amino-2,6-dimethylhept-1-en-3-one trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1039/c4ob00893f

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 1619233-32-7
(S)-4-amino-2,6-dimethylhept-1-en-3-one trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 2 h / Inert atmosphere

2.1: tert.-butyl lithium / diethyl ether; pentane / 0.5 h / -78 °C / Inert atmosphere

2.2: 2.5 h / -78 - 20 °C / Inert atmosphere

3.1: dichloromethane / 0.5 h / 20 °C / Inert atmosphere

With tert.-butyl lithium; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; pentane;
DOI:10.1039/c4ob00893f

Reference yield:

: 87694-50-6
N-(tert-butoxycarbonyl)-L-leucine-N'-methoxy-N'-methylamide

: 1619233-32-7
(S)-4-amino-2,6-dimethylhept-1-en-3-one trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tert.-butyl lithium / diethyl ether; pentane / 0.5 h / -78 °C / Inert atmosphere

1.2: 2.5 h / -78 - 20 °C / Inert atmosphere

2.1: dichloromethane / 0.5 h / 20 °C / Inert atmosphere

With tert.-butyl lithium; In diethyl ether; dichloromethane; pentane;
DOI:10.1039/c4ob00893f