(2S,4S,5S,7S)-5-amino-N-(2,2-dimethyl-3-(2-phenylacetamido)propyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide

Base Information

• Chemical Name: (2S,4S,5S,7S)-5-amino-N-(2,2-dimethyl-3-(2-phenylacetamido)propyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide
• CAS No.: 1321622-31-4
• Molecular Formula: C₃₈H₆₁N₃O₆
• Molecular Weight: 655.919
• Mol file: 1321622-31-4.mol

Synonyms:(2S,4S,5S,7S)-5-amino-N-(2,2-dimethyl-3-(2-phenylacetamido)propyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide

Chemical Property of (2S,4S,5S,7S)-5-amino-N-(2,2-dimethyl-3-(2-phenylacetamido)propyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,4S,5S,7S)-5-amino-N-(2,2-dimethyl-3-(2-phenylacetamido)propyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide

There total 8 articles about (2S,4S,5S,7S)-5-amino-N-(2,2-dimethyl-3-(2-phenylacetamido)propyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(2S,4S,5S,7S)-5-azido-N-(2,2-dimethyl-3-(2-phenylacetamido)propyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide (1321622-49-4) → (2S,4S,5S,7S)-5-amino-N-(2,2-dimethyl-3-(2-phenylacetamido)propyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide (1321622-31-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; ethanolamine; In tert-butyl methyl ether; at 25 ℃;

DOI:10.1016/j.bmc.2011.05.059

Reference yield:

N-(3-azido-2,2-dimethylpropyl)-2-phenylacetamide (1321622-83-6) → (2S,4S,5S,7S)-5-amino-N-(2,2-dimethyl-3-(2-phenylacetamido)propyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide (1321622-31-4)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 25 °C

2: 2-hydroxypyridin; triethylamine / 65 °C

3: palladium 10% on activated carbon; hydrogen; ethanolamine / tert-butyl methyl ether / 25 °C

With 2-hydroxypyridin; palladium 10% on activated carbon; hydrogen; ethanolamine; triethylamine; In methanol; tert-butyl methyl ether;

DOI:10.1016/j.bmc.2011.05.059

Reference yield:

N-(3-amino-2,2-dimethylpropyl)-2-phenylacetamide (1321622-67-6) → (2S,4S,5S,7S)-5-amino-N-(2,2-dimethyl-3-(2-phenylacetamido)propyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide (1321622-31-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 2-hydroxypyridin; triethylamine / 65 °C

2: palladium 10% on activated carbon; hydrogen; ethanolamine / tert-butyl methyl ether / 25 °C

With 2-hydroxypyridin; palladium 10% on activated carbon; hydrogen; ethanolamine; triethylamine; In tert-butyl methyl ether;

DOI:10.1016/j.bmc.2011.05.059

upstream raw materials:

N-(3-azido-2,2-dimethylpropyl)-2-phenylacetamide

2-(3-bromo-2, 2-dimethylpropyl)-2,3-dihydro-1H-isoindole-1,3-dione

N-(3-amino-2,2-dimethylpropyl)-2-phenylacetamide

2-(3-azido-2,2-dimethylpropyl)isoindoline-1,3-dione