(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)phenoxy)carbonyloxy)ethyl)pyridine 1-oxide?

Base Information

Chemical Name:(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)phenoxy)carbonyloxy)ethyl)pyridine 1-oxide?
CAS No.:1428847-98-6
Molecular Formula:C₃₃H₃₇Cl₂F₂N₃O₁₀S
Molecular Weight:776.64
Hs Code.:

(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)phenoxy)carbonyloxy)ethyl)pyridine 1-oxide?

Synonyms:(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)phenoxy)carbonyloxy)ethyl)pyridine 1-oxide?

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Chemical Property of (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)phenoxy)carbonyloxy)ethyl)pyridine 1-oxide?

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Technology Process of (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)phenoxy)carbonyloxy)ethyl)pyridine 1-oxide?

There total 8 articles about (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)phenoxy)carbonyloxy)ethyl)pyridine 1-oxide? which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.2%

: 1428846-77-8
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((4-nitrophenoxy)carbonyloxy)-ethyl)pyridine 1-oxide

: 1428848-02-5
N-(5-hydroxy-2-methoxyphenyl)-N-(2-morpholinoethyl)methanesulfonamide

: 1428847-98-6
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)phenoxy)carbonyloxy)ethyl)pyridine 1-oxide?

Guidance literature:: With dmap; In N,N-dimethyl-formamide; at 20 ℃; for 7h;

Reference yield:

: (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-hydroxyethyl)pyridine 1-oxide

: 1428847-98-6
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)phenoxy)carbonyloxy)ethyl)pyridine 1-oxide?

Guidance literature:: Multi-step reaction with 2 steps

1: dmap / dichloromethane / 18 h / 20 °C

2: dmap / N,N-dimethyl-formamide / 7 h / 20 °C

With dmap; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: ethyl 4-methoxy-3-nitrophenyl carbonate

: 1428847-98-6
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)phenoxy)carbonyloxy)ethyl)pyridine 1-oxide?

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium 10% on activated carbon; hydrogen; acetic acid / ethyl acetate / 2 h / 1292.9 Torr

2.1: pyridine / dichloromethane / 3 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C / Inert atmosphere

3.2: 2 h / 90 °C

4.1: water; lithium hydroxide / methanol / 4 h / 20 °C

4.2: pH 5

5.1: dmap / N,N-dimethyl-formamide / 7 h / 20 °C

With pyridine; dmap; palladium 10% on activated carbon; water; hydrogen; sodium hydride; acetic acid; lithium hydroxide; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;