(E)-3-phenylacrylic acid 4'-[(E)-(3-phenylacryloyl)oxymethyl]-[2,2']bipyridinyl-4-ylmethyl ester

Base Information

• Chemical Name: (E)-3-phenylacrylic acid 4'-[(E)-(3-phenylacryloyl)oxymethyl]-[2,2']bipyridinyl-4-ylmethyl ester
• CAS No.: 866789-01-7
• Molecular Formula: C₃₀H₂₄N₂O₄
• Molecular Weight: 476.532
• Mol file: 866789-01-7.mol

Synonyms:(E)-3-phenylacrylic acid 4'-[(E)-(3-phenylacryloyl)oxymethyl]-[2,2']bipyridinyl-4-ylmethyl ester

Chemical Property of (E)-3-phenylacrylic acid 4'-[(E)-(3-phenylacryloyl)oxymethyl]-[2,2']bipyridinyl-4-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-phenylacrylic acid 4'-[(E)-(3-phenylacryloyl)oxymethyl]-[2,2']bipyridinyl-4-ylmethyl ester

There total 1 articles about (E)-3-phenylacrylic acid 4'-[(E)-(3-phenylacryloyl)oxymethyl]-[2,2']bipyridinyl-4-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,4'-bis(hydroxymethyl)-2,2'-bipyridine (109073-77-0) → (E)-3-phenylacrylic acid 4'-[(E)-(3-phenylacryloyl)oxymethyl]-[2,2']bipyridinyl-4-ylmethyl ester (866789-01-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 85 percent / diisopropylcarbodiimide / CH₂Cl₂; tetrahydrofuran / 0.33 h / 100 °C / microwave irradiation

2.1: t-BuOK / tetrahydrofuran / 0.25 h / 0 °C

2.2: 98 percent / tetrahydrofuran / 0 - 25 °C

With potassium tert-butylate; diisopropyl-carbodiimide; In tetrahydrofuran; dichloromethane; 2.2: Horner-Emmons reaction;

DOI:10.1039/b503778f

Reference yield: 95.0%

(E)-3-phenylacrylic acid 4'-[(E)-(3-phenylacryloyl)oxymethyl]-[2,2']bipyridinyl-4-ylmethyl ester (866789-01-7) → Methyl cinnamate (103-26-4,1754-62-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; methanol; at 120 ℃; for 2h; microwave irradiation;

DOI:10.1039/b503778f

Reference yield: 92.0%

(E)-3-phenylacrylic acid 4'-[(E)-(3-phenylacryloyl)oxymethyl]-[2,2']bipyridinyl-4-ylmethyl ester (866789-01-7) + butanone (78-93-3) → 4-methyl-5-phenylcyclohexane-1,3-dione (384332-81-4)

Guidance literature:

butanone; With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 0.333333h;

(E)-3-phenylacrylic acid 4'-[(E)-(3-phenylacryloyl)oxymethyl]-[2,2']bipyridinyl-4-ylmethyl ester; In tetrahydrofuran; at 70 ℃; for 0.75h; microwave irradiation;

DOI:10.1039/b503778f

upstream raw materials:

4,4'-bis(hydroxymethyl)-2,2'-bipyridine

Downstream raw materials:

Methyl cinnamate

4-methoxy-6-phenylpyrimidin-2-ylamine

4-methyl-5-phenylcyclohexane-1,3-dione