(2SR,3SR,γSR)-1-(Benzyloxycarbonyl)-3-<2-(trimethylsilyl)ethoxymethoxy>-γ-<2-(trimethylsilyl)ethoxymethoxymethyl>pyrrolidine-2-propanol

Base Information

Chemical Name:(2SR,3SR,γSR)-1-(Benzyloxycarbonyl)-3-<2-(trimethylsilyl)ethoxymethoxy>-γ-<2-(trimethylsilyl)ethoxymethoxymethyl>pyrrolidine-2-propanol
CAS No.:135905-10-1
Molecular Formula:C₂₈H₅₁NO₇Si₂
Molecular Weight:569.886
Hs Code.:

Synonyms:(2SR,3SR,γSR)-1-(Benzyloxycarbonyl)-3-<2-(trimethylsilyl)ethoxymethoxy>-γ-<2-(trimethylsilyl)ethoxymethoxymethyl>pyrrolidine-2-propanol

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Chemical Property of (2SR,3SR,γSR)-1-(Benzyloxycarbonyl)-3-<2-(trimethylsilyl)ethoxymethoxy>-γ-<2-(trimethylsilyl)ethoxymethoxymethyl>pyrrolidine-2-propanol

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Technology Process of (2SR,3SR,γSR)-1-(Benzyloxycarbonyl)-3-<2-(trimethylsilyl)ethoxymethoxy>-γ-<2-(trimethylsilyl)ethoxymethoxymethyl>pyrrolidine-2-propanol

There total 8 articles about (2SR,3SR,γSR)-1-(Benzyloxycarbonyl)-3-<2-(trimethylsilyl)ethoxymethoxy>-γ-<2-(trimethylsilyl)ethoxymethoxymethyl>pyrrolidine-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: (2R,3R)-2-[(R)-3-Oxo-1-(2-trimethylsilanyl-ethoxymethoxymethyl)-propyl]-3-(2-trimethylsilanyl-ethoxymethoxy)-pyrrolidine-1-carboxylic acid benzyl ester

: 135905-10-1
(2SR,3SR,γSR)-1-(Benzyloxycarbonyl)-3-<2-(trimethylsilyl)ethoxymethoxy>-γ-<2-(trimethylsilyl)ethoxymethoxymethyl>pyrrolidine-2-propanol

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 0 ℃; for 0.5h;

Reference yield:

: 135905-08-7
(2SR,3SR,1'SR)-1-(Benzyloxycarbonyl)-3-<2-(trimethylsilyl)ethoxymethoxy>-2-<<2-(trimethylsilyl)ethoxymethoxymethyl>but-3'-en-1'-yl>pyrrolidine

: 135905-10-1
(2SR,3SR,γSR)-1-(Benzyloxycarbonyl)-3-<2-(trimethylsilyl)ethoxymethoxy>-γ-<2-(trimethylsilyl)ethoxymethoxymethyl>pyrrolidine-2-propanol

Guidance literature:: With sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; Yield given. Multistep reaction;

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 135905-10-1
(2SR,3SR,γSR)-1-(Benzyloxycarbonyl)-3-<2-(trimethylsilyl)ethoxymethoxy>-γ-<2-(trimethylsilyl)ethoxymethoxymethyl>pyrrolidine-2-propanol

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 16 h / 40 °C

2: NaIO₄, OsO₄ / diethyl ether; H₂O / 16 h / Ambient temperature

3: 67 percent / NaBH₄ / ethanol / 0.5 h / 0 °C

With sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; N-ethyl-N,N-diisopropylamine; In diethyl ether; ethanol; dichloromethane; water;