(3-chloro-7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazolo-[1,5-a]pyrimidin-6-yl)(4-(4-fluorophenyl)piperazin-1-yl)methanone

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Chemical Name:(3-chloro-7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazolo-[1,5-a]pyrimidin-6-yl)(4-(4-fluorophenyl)piperazin-1-yl)methanone
CAS No.:343245-11-4
Molecular Formula:C₂₄H₂₁Cl₃FN₅O
Molecular Weight:520.821
Hs Code.:

Synonyms:(3-chloro-7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazolo-[1,5-a]pyrimidin-6-yl)(4-(4-fluorophenyl)piperazin-1-yl)methanone

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Chemical Property of (3-chloro-7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazolo-[1,5-a]pyrimidin-6-yl)(4-(4-fluorophenyl)piperazin-1-yl)methanone

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Technology Process of (3-chloro-7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazolo-[1,5-a]pyrimidin-6-yl)(4-(4-fluorophenyl)piperazin-1-yl)methanone

There total 3 articles about (3-chloro-7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazolo-[1,5-a]pyrimidin-6-yl)(4-(4-fluorophenyl)piperazin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 343242-12-6,343242-13-7,1099712-30-7
1-[[7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluorophenyl)piperazine

: 343245-11-4
(3-chloro-7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazolo-[1,5-a]pyrimidin-6-yl)(4-(4-fluorophenyl)piperazin-1-yl)methanone

Guidance literature:: With N-chloro-succinimide; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/jm201386u

Reference yield:

: 414895-05-9
1-(4-(4-fluorophenyl)piperazin-1-yl)butane-1,3-dione

: 343245-11-4
(3-chloro-7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazolo-[1,5-a]pyrimidin-6-yl)(4-(4-fluorophenyl)piperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: sodium acetate / N,N-dimethyl-formamide / 14 h / 65 °C / Inert atmosphere

2: N-chloro-succinimide / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

With N-chloro-succinimide; sodium acetate; In dichloromethane; N,N-dimethyl-formamide; 1: Biginelli reaction;
DOI:10.1021/jm201386u

Reference yield:

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 343245-11-4
(3-chloro-7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazolo-[1,5-a]pyrimidin-6-yl)(4-(4-fluorophenyl)piperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: toluene / 4 h / 120 °C / Inert atmosphere

2: sodium acetate / N,N-dimethyl-formamide / 14 h / 65 °C / Inert atmosphere

3: N-chloro-succinimide / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

With N-chloro-succinimide; sodium acetate; In dichloromethane; N,N-dimethyl-formamide; toluene; 2: Biginelli reaction;
DOI:10.1021/jm201386u