6-(4-Chlorophenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-amine

Base Information

• Chemical Name: 6-(4-Chlorophenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-amine
• CAS No.: 16163-53-4
• Molecular Formula: C10H7 Cl N4 S
• Molecular Weight: 250.71
• DSSTox Substance ID: DTXSID50936567
• Wikidata: Q82912786
• Mol file: 16163-53-4.mol

Synonyms:6-(4-chlorophenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-amine;DTXSID50936567;AKOS022555606;CS-0285144;EN300-35511;SR-01000044396;SR-01000044396-1;Z56924498;6-(4-Chlorophenyl)imidazo[2,1-b][1,3,4]thiadiazol-2(3H)-imine

Chemical Property of 6-(4-Chlorophenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-amine

Chemical Property:

• Melting Point: 266-269 °C(Solv: ethanol (64-17-5))
• Boiling Point: °Cat760mmHg
• PKA: 2.12±0.50(Predicted)
• Flash Point: °C
• PSA: 84.45000
• Density: 1.68g/cm³
• LogP: 3.27460
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 250.0079951
• Heavy Atom Count: 16
• Complexity: 259

Purity/Quality:

97% ^*data from raw suppliers

6-(4-CHLOROPHENYL)IMIDAZO[2,1-B][1,3,4]THIADIAZOL-2-AMINE HYDROBROMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C2=CN3C(=N2)SC(=N3)N)Cl

Technology Process of 6-(4-Chlorophenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-amine

There total 2 articles about 6-(4-Chlorophenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 6-(4-chloro-phenyl)-imidazo[2,1-b][1,3,4]thiadiazol-2-ylamine (16163-53-4)

Guidance literature:

Thiadiazolin-hydrohalogenid (4d), NH3;

DOI:10.1007/BF00912812

Reference yield:

→ 2-Amino-6-(4-chlorphenyl)-imidazo(2,1-b)-1,3,4-thiadiazol (16163-53-4)

Guidance literature:

3-(4-Chlor-phenacyl)-5-amino-2-imino-1,3,4-thiadiazolin-hydrobromid ,sd.W.;

Reference yield: 92.0%

2-Amino-6-(4-chlorphenyl)-imidazo(2,1-b)-1,3,4-thiadiazol (16163-53-4) + succinic acid diethyl ester (123-25-1) → 6-(4-Chlorphenyl)-2-succinimido-imidazo<2,1-b>-1,3,4-thiadiazol (81124-65-4)

Guidance literature:

With PPA; at 120 ℃; for 7h;

DOI:10.1002/ardp.19823150105

Downstream raw materials:

N-[6-(4-Chloro-phenyl)-imidazo[2,1-b][1,3,4]thiadiazol-2-yl]-3-oxo-butyramide

6-(4-Chlorphenyl)-2-succinimido-imidazo<2,1-b>-1,3,4-thiadiazol

2-[6-(4-Chloro-phenyl)-imidazo[2,1-b][1,3,4]thiadiazol-2-yl]-isoindole-1,3-dione

2-(4-Chlorphenyl)-8-methyl-imidazo<2,1-b>-1,3,4-thiadiazolo-<3,2-a>pyrimidon-(6)

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