7-benzyloxy-6-[4-(3-benzyloxy-4,5,6,8-tetramethoxynaphthalen-2-yl)-1-(tert-butyldiphenylsilanyloxy)-3-oxobutyl]-8-methoxy-1-oxo-1H-isochromene-3-carboxylic acid methyl ester

Base Information

Chemical Name:7-benzyloxy-6-[4-(3-benzyloxy-4,5,6,8-tetramethoxynaphthalen-2-yl)-1-(tert-butyldiphenylsilanyloxy)-3-oxobutyl]-8-methoxy-1-oxo-1H-isochromene-3-carboxylic acid methyl ester
CAS No.:1315508-18-9
Molecular Formula:C₆₀H₆₀O₁₃Si
Molecular Weight:1017.21
Hs Code.:

7-benzyloxy-6-[4-(3-benzyloxy-4,5,6,8-tetramethoxynaphthalen-2-yl)-1-(tert-butyldiphenylsilanyloxy)-3-oxobutyl]-8-methoxy-1-oxo-1H-isochromene-3-carboxylic acid methyl ester

Synonyms:7-benzyloxy-6-[4-(3-benzyloxy-4,5,6,8-tetramethoxynaphthalen-2-yl)-1-(tert-butyldiphenylsilanyloxy)-3-oxobutyl]-8-methoxy-1-oxo-1H-isochromene-3-carboxylic acid methyl ester

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Chemical Property of 7-benzyloxy-6-[4-(3-benzyloxy-4,5,6,8-tetramethoxynaphthalen-2-yl)-1-(tert-butyldiphenylsilanyloxy)-3-oxobutyl]-8-methoxy-1-oxo-1H-isochromene-3-carboxylic acid methyl ester

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Technology Process of 7-benzyloxy-6-[4-(3-benzyloxy-4,5,6,8-tetramethoxynaphthalen-2-yl)-1-(tert-butyldiphenylsilanyloxy)-3-oxobutyl]-8-methoxy-1-oxo-1H-isochromene-3-carboxylic acid methyl ester

There total 10 articles about 7-benzyloxy-6-[4-(3-benzyloxy-4,5,6,8-tetramethoxynaphthalen-2-yl)-1-(tert-butyldiphenylsilanyloxy)-3-oxobutyl]-8-methoxy-1-oxo-1H-isochromene-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1315508-17-8
7-benzyloxy-6-[4-(3-benzyloxy-4,5,6,8-tetramethoxynaphthalen-2-yl)-1-hydroxy-3-oxobutyl]-8-methoxy-1-oxo-1Hisochromene-3-carboxylic acid methyl ester

: 69739-34-0
t-butyldimethylsiyl triflate

: 1315508-18-9
7-benzyloxy-6-[4-(3-benzyloxy-4,5,6,8-tetramethoxynaphthalen-2-yl)-1-(tert-butyldiphenylsilanyloxy)-3-oxobutyl]-8-methoxy-1-oxo-1H-isochromene-3-carboxylic acid methyl ester

Guidance literature:: With 1H-imidazole; triethylamine; In dichloromethane; for 21h; Inert atmosphere; Darkness;
DOI:10.1021/jo200399z

Reference yield:

: 1012037-70-5
ethyl 3,4-dihydro-5,6,8-trimethoxy-3,4-dioxonaphthalene-2-carboxylate

: 1315508-18-9
7-benzyloxy-6-[4-(3-benzyloxy-4,5,6,8-tetramethoxynaphthalen-2-yl)-1-(tert-butyldiphenylsilanyloxy)-3-oxobutyl]-8-methoxy-1-oxo-1H-isochromene-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: sodium dithionite; water / benzene / 0.08 h

2: potassium carbonate / N,N-dimethyl-formamide / 120 h

3: potassium carbonate / N,N-dimethyl-formamide / 22 h / 20 °C

4: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Cooling with ice

5: Dess-Martin periodane / dichloromethane / 1.1 h / Cooling with ice

6: ammonium acetate / 13 h / 120 °C

7: sodium tetrahydroborate / methanol; dichloromethane / 0.25 h / Cooling with ice

8: phenyl isocyanate; triethylamine / benzene / 40 h / 45 - 50 °C

9: hydrogen; boric acid / tetrahydrofuran; methanol; water / 21 h

10: 1H-imidazole; triethylamine / dichloromethane / 21 h / Inert atmosphere; Darkness

With 1H-imidazole; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium dithionite; ammonium acetate; water; hydrogen; boric acid; potassium carbonate; Dess-Martin periodane; phenyl isocyanate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo200399z

Reference yield:

: C₁₆H₁₈O₇

: 1315508-18-9
7-benzyloxy-6-[4-(3-benzyloxy-4,5,6,8-tetramethoxynaphthalen-2-yl)-1-(tert-butyldiphenylsilanyloxy)-3-oxobutyl]-8-methoxy-1-oxo-1H-isochromene-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: potassium carbonate / N,N-dimethyl-formamide / 120 h

2: potassium carbonate / N,N-dimethyl-formamide / 22 h / 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Cooling with ice

4: Dess-Martin periodane / dichloromethane / 1.1 h / Cooling with ice

5: ammonium acetate / 13 h / 120 °C

6: sodium tetrahydroborate / methanol; dichloromethane / 0.25 h / Cooling with ice

7: phenyl isocyanate; triethylamine / benzene / 40 h / 45 - 50 °C

8: hydrogen; boric acid / tetrahydrofuran; methanol; water / 21 h

9: 1H-imidazole; triethylamine / dichloromethane / 21 h / Inert atmosphere; Darkness

With 1H-imidazole; sodium tetrahydroborate; lithium aluminium tetrahydride; ammonium acetate; hydrogen; boric acid; potassium carbonate; Dess-Martin periodane; phenyl isocyanate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo200399z