5-(Acetylamino)-3-methoxy-2-nitrobenzoic acid

Base Information

Chemical Name:5-(Acetylamino)-3-methoxy-2-nitrobenzoic acid
CAS No.:78238-04-7
Molecular Formula:C₁₀H₁₀N₂O₆
Molecular Weight:254.199
Hs Code.:
DSSTox Substance ID:DTXSID501253916

Synonyms:5-(Acetylamino)-3-methoxy-2-nitrobenzoic acid;DTXSID501253916;78238-04-7

Suppliers and Price of 5-(Acetylamino)-3-methoxy-2-nitrobenzoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(Acetylamino)-3-methoxy-2-nitrobenzoic acid

Chemical Property:

XLogP3:0.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:254.05388604
Heavy Atom Count:18
Complexity:353

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=O)NC1=CC(=C(C(=C1)OC)[N+](=O)[O-])C(=O)O

Technology Process of 5-(Acetylamino)-3-methoxy-2-nitrobenzoic acid

There total 3 articles about 5-(Acetylamino)-3-methoxy-2-nitrobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 78238-03-6
3-methoxy-5-acetylaminobenzoic acid

: 78238-04-7
2-nitro-3-methoxy-5-acetylaminobenzoic acid

Guidance literature:: With sulfuric acid; nitric acid; at -30 ℃;

Reference yield:

: 78238-12-7
3-methoxy-5-nitrobenzoic acid

: 78238-04-7
2-nitro-3-methoxy-5-acetylaminobenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1) 20percent aq. NaOH, 98percent hydrazine hydrate, Raney nickel / 1) water, 70 to 75 deg. C; 2) 70 to 80 deg. C, 30 min

2: 71 percent / H₂SO₄ (d 1.83), HNO₃ (d1.51) / -30 °C

With sodium hydroxide; sulfuric acid; nitric acid; nickel; hydrazine hydrate;

Reference yield:

: 78238-13-8
3-methoxy-5-nitrobenzoic acid methyl ester

: 78238-04-7
2-nitro-3-methoxy-5-acetylaminobenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: HCl (d 1.17) / 0.5 h

2: 1) 20percent aq. NaOH, 98percent hydrazine hydrate, Raney nickel / 1) water, 70 to 75 deg. C; 2) 70 to 80 deg. C, 30 min

3: 71 percent / H₂SO₄ (d 1.83), HNO₃ (d1.51) / -30 °C

With hydrogenchloride; sodium hydroxide; sulfuric acid; nitric acid; nickel; hydrazine hydrate;