N-{6-[(tert-butyl-dimethyl-silanyloxy)-(2-chloro-6-fluoro-phenyl)-methyl]-imidazo[1,2-a]pyridin-2-yl}-2,2,2-trifluoro-acetamide

Base Information

• Chemical Name: N-{6-[(tert-butyl-dimethyl-silanyloxy)-(2-chloro-6-fluoro-phenyl)-methyl]-imidazo[1,2-a]pyridin-2-yl}-2,2,2-trifluoro-acetamide
• CAS No.: 504413-38-1
• Molecular Formula: C₂₂H₂₄ClF₄N₃O₂Si
• Molecular Weight: 501.984

Synonyms:N-{6-[(tert-butyl-dimethyl-silanyloxy)-(2-chloro-6-fluoro-phenyl)-methyl]-imidazo[1,2-a]pyridin-2-yl}-2,2,2-trifluoro-acetamide

Chemical Property of N-{6-[(tert-butyl-dimethyl-silanyloxy)-(2-chloro-6-fluoro-phenyl)-methyl]-imidazo[1,2-a]pyridin-2-yl}-2,2,2-trifluoro-acetamide

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Technology Process of N-{6-[(tert-butyl-dimethyl-silanyloxy)-(2-chloro-6-fluoro-phenyl)-methyl]-imidazo[1,2-a]pyridin-2-yl}-2,2,2-trifluoro-acetamide

There total 3 articles about N-{6-[(tert-butyl-dimethyl-silanyloxy)-(2-chloro-6-fluoro-phenyl)-methyl]-imidazo[1,2-a]pyridin-2-yl}-2,2,2-trifluoro-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

t-butyldimethylsiyl triflate (69739-34-0) + N-{6-[(2-chloro-6-fluoro-phenyl)-hydroxy-methyl]-imidazo[1,2-a]pyridin-2-yl}-2,2,2-trifluoro-acetamide (504413-29-0) → N-{6-[(tert-butyl-dimethyl-silanyloxy)-(2-chloro-6-fluoro-phenyl)-methyl]-imidazo[1,2-a]pyridin-2-yl}-2,2,2-trifluoro-acetamide (504413-38-1)

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃;

DOI:10.1016/S0040-4039(02)02278-5

Reference yield:

2-chloro-6-fluorobenzaldehyde (387-45-1) → N-{6-[(tert-butyl-dimethyl-silanyloxy)-(2-chloro-6-fluoro-phenyl)-methyl]-imidazo[1,2-a]pyridin-2-yl}-2,2,2-trifluoro-acetamide (504413-38-1)

Guidance literature:

Multi-step reaction with 2 steps

1: i-PrMgCl

With isopropylmagnesium chloride;

DOI:10.1016/j.bmcl.2004.09.053

Reference yield:

2,2,2-trifluoro-N-(6-iodoimidazo[1,2-a]pyridin-2-yl)acetamide (209971-49-3) → N-{6-[(tert-butyl-dimethyl-silanyloxy)-(2-chloro-6-fluoro-phenyl)-methyl]-imidazo[1,2-a]pyridin-2-yl}-2,2,2-trifluoro-acetamide (504413-38-1)

Guidance literature:

Multi-step reaction with 2 steps

1: i-PrMgCl

With isopropylmagnesium chloride;

DOI:10.1016/j.bmcl.2004.09.053

upstream raw materials:

t-butyldimethylsiyl triflate

N-{6-[(2-chloro-6-fluoro-phenyl)-hydroxy-methyl]-imidazo[1,2-a]pyridin-2-yl}-2,2,2-trifluoro-acetamide

2-chloro-6-fluorobenzaldehyde

2,2,2-trifluoro-N-(6-iodoimidazo[1,2-a]pyridin-2-yl)acetamide

Downstream raw materials:

N-[6-[(tert-butyl-dimethyl-silanyloxy)-(2-chloro-6-fluoro-phenyl)-methyl]-3-(2,6-difluoro-benzoyl)-imidazo[1,2-a]pyridin-2-yl]-2,2,2-trifluoro-acetamide

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