2-(benzyloxy)-6-(1H-indol-3-ylmethyl)-3-isobutyl-5-methoxypyrazine 4-oxide

Base Information

• Chemical Name: 2-(benzyloxy)-6-(1H-indol-3-ylmethyl)-3-isobutyl-5-methoxypyrazine 4-oxide
• CAS No.: 131827-25-3
• Molecular Formula: C₂₅H₂₇N₃O₃
• Molecular Weight: 417.508
• Mol file: 131827-25-3.mol

Synonyms:2-(benzyloxy)-6-(1H-indol-3-ylmethyl)-3-isobutyl-5-methoxypyrazine 4-oxide

Chemical Property of 2-(benzyloxy)-6-(1H-indol-3-ylmethyl)-3-isobutyl-5-methoxypyrazine 4-oxide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-(benzyloxy)-6-(1H-indol-3-ylmethyl)-3-isobutyl-5-methoxypyrazine 4-oxide

There total 5 articles about 2-(benzyloxy)-6-(1H-indol-3-ylmethyl)-3-isobutyl-5-methoxypyrazine 4-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-(benzyloxy)-6-(iodomethyl)-3-isobutyl-5-methoxypyrazine 4-oxide (131828-33-6) + indolylzinc chloride → 2-(benzyloxy)-6-(1H-indol-3-ylmethyl)-3-isobutyl-5-methoxypyrazine 4-oxide (131827-25-3)

Guidance literature:

In toluene; for 1h; Product distribution; Ambient temperature; other reactants, other solvents, temp.;

DOI:10.1021/jo00016a012

Reference yield:

indole (120-72-9) + 2-(benzyloxy)-6-(iodomethyl)-3-isobutyl-5-methoxypyrazine 4-oxide (131828-33-6) → 2-(benzyloxy)-6-(1H-indol-3-ylmethyl)-3-isobutyl-5-methoxypyrazine 4-oxide (131827-25-3)

Guidance literature:

With n-butyllithium; Zinc chloride; In tetrahydrofuran; hexane; toluene;

Reference yield:

3-benzyloxy-5-[(1-methoxycarbonyl)indol-3-yl]methyl-2-isobutyl-6-methoxypyrazine 1-oxide (131827-33-3) → 2-(benzyloxy)-6-(1H-indol-3-ylmethyl)-3-isobutyl-5-methoxypyrazine 4-oxide (131827-25-3)

Guidance literature:

With hydrogenchloride; potassium hydroxide; In methanol-tetrahydrofuran; dichloromethane;

upstream raw materials:

2-(benzyloxy)-6-(iodomethyl)-3-isobutyl-5-methoxypyrazine 4-oxide

indole

3-benzyloxy-5-[(1-methoxycarbonyl)indol-3-yl]methyl-2-isobutyl-6-methoxypyrazine 1-oxide

Downstream raw materials:

6-(indol-3-yl)methyl-3-isobutyl-5-methoxy-1,2-dihydropyrazin-2-one 4-oxide