4-(2-methoxyethyl)-7-(phenoxymethyl)-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine

Base Information

Chemical Name:4-(2-methoxyethyl)-7-(phenoxymethyl)-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine
CAS No.:1287312-52-0
Molecular Formula:C₁₇H₂₀N₂O₃
Molecular Weight:300.357
Hs Code.:

Synonyms:4-(2-methoxyethyl)-7-(phenoxymethyl)-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(2-methoxyethyl)-7-(phenoxymethyl)-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine

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Technology Process of 4-(2-methoxyethyl)-7-(phenoxymethyl)-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine

There total 7 articles about 4-(2-methoxyethyl)-7-(phenoxymethyl)-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.0%

: 1287312-48-4
7-(phenoxymethyl)-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine

: 6482-24-2
2-Bromoethyl methyl ether

: 1287312-52-0
4-(2-methoxyethyl)-7-(phenoxymethyl)-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 0.25h;
DOI:10.1016/j.bmcl.2011.01.027

Reference yield:

: 1287312-61-1
tert-butyl 7-vinyl-2H-pyrido[3,2-b][1,4]oxazine-4(3H)-carboxylate

: 1287312-52-0
4-(2-methoxyethyl)-7-(phenoxymethyl)-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine

Guidance literature:: Multi-step reaction with 5 steps

1: sodium periodate; osmium(VIII) oxide; tert-butyl alcohol / tetrahydrofuran; water / 1 h / 20 °C

2: sodium tetrahydroborate / methanol / 0.25 h

3: triphenylphosphine; diethylazodicarboxylate / dichloromethane; toluene / 18 h

4: hydrogenchloride / water

5: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h

With hydrogenchloride; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; sodium hydride; triphenylphosphine; tert-butyl alcohol; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil; 3: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2011.01.027

Reference yield:

: 1287312-63-3
tert-butyl 7-(hydroxymethyl)-2H-pyrido[3,2-b][1,4]oxazine-4(3H)-carboxylate

: 1287312-52-0
4-(2-methoxyethyl)-7-(phenoxymethyl)-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; diethylazodicarboxylate / dichloromethane; toluene / 18 h

2: hydrogenchloride / water

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h

With hydrogenchloride; sodium hydride; triphenylphosphine; diethylazodicarboxylate; In dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil; 1: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2011.01.027