methyl 6-[[4-[2-fluoro-4-[[1-[(4-fluorophenyl)aminocarbonyl]cyclopropanecarbonyl]amino]phenoxy]-6-methoxy-7-quinolyl]oxy]hexanoate

Base Information

Chemical Name:methyl 6-[[4-[2-fluoro-4-[[1-[(4-fluorophenyl)aminocarbonyl]cyclopropanecarbonyl]amino]phenoxy]-6-methoxy-7-quinolyl]oxy]hexanoate
CAS No.:1372671-46-9
Molecular Formula:C₃₄H₃₃F₂N₃O₇
Molecular Weight:633.649
Hs Code.:

Synonyms:methyl 6-[[4-[2-fluoro-4-[[1-[(4-fluorophenyl)aminocarbonyl]cyclopropanecarbonyl]amino]phenoxy]-6-methoxy-7-quinolyl]oxy]hexanoate

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Chemical Property of methyl 6-[[4-[2-fluoro-4-[[1-[(4-fluorophenyl)aminocarbonyl]cyclopropanecarbonyl]amino]phenoxy]-6-methoxy-7-quinolyl]oxy]hexanoate

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Technology Process of methyl 6-[[4-[2-fluoro-4-[[1-[(4-fluorophenyl)aminocarbonyl]cyclopropanecarbonyl]amino]phenoxy]-6-methoxy-7-quinolyl]oxy]hexanoate

There total 4 articles about methyl 6-[[4-[2-fluoro-4-[[1-[(4-fluorophenyl)aminocarbonyl]cyclopropanecarbonyl]amino]phenoxy]-6-methoxy-7-quinolyl]oxy]hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14273-90-6
methyl 6-bromohexanoate

: 849217-50-1
N-[3-fluoro-4-[[7-hydroxy-6-methoxy-quinolin-4-yl]oxy]phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

: 1372671-46-9
methyl 6-[[4-[2-fluoro-4-[[1-[(4-fluorophenyl)aminocarbonyl]cyclopropanecarbonyl]amino]phenoxy]-6-methoxy-7-quinolyl]oxy]hexanoate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1372671-34-5
4-(4-amino-2-fluorophenyloxy)-6-methoxy-7-hydroxyquinoline hydrobromide

: 1372671-46-9
methyl 6-[[4-[2-fluoro-4-[[1-[(4-fluorophenyl)aminocarbonyl]cyclopropanecarbonyl]amino]phenoxy]-6-methoxy-7-quinolyl]oxy]hexanoate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; HATU; dmap / N,N-dimethyl-formamide / 30 - 40 °C

2: caesium carbonate / N,N-dimethyl-formamide / 20 °C

With dmap; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide;

Reference yield:

: 4-(2-fluoro-4-nitrophenoxy)-6-methoxy-7-hydroxyquinoline hydrobromide

: 1372671-46-9
methyl 6-[[4-[2-fluoro-4-[[1-[(4-fluorophenyl)aminocarbonyl]cyclopropanecarbonyl]amino]phenoxy]-6-methoxy-7-quinolyl]oxy]hexanoate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / methanol / 19 h / 20 °C / 1551.49 Torr

2: N-ethyl-N,N-diisopropylamine; HATU; dmap / N,N-dimethyl-formamide / 30 - 40 °C

3: caesium carbonate / N,N-dimethyl-formamide / 20 °C

With dmap; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In methanol; N,N-dimethyl-formamide;