3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

Base Information

Chemical Name:3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide
CAS No.:1336960-25-8
Molecular Formula:C₃₆H₃₇F₃N₄O₂
Molecular Weight:614.711
Hs Code.:

Synonyms:3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

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Chemical Property of 3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

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Technology Process of 3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

There total 7 articles about 3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1336905-19-1
3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

: 41049-53-0,773012-60-5
1-phenylcyclopropylamine

: 1336960-25-8
3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; HATU; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1533-03-5
3-(trifluoromethyl)propiophenone

: 1336960-25-8
3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide / ethanol; water / 0.25 h

1.2: 1 h / Reflux

1.3: pH 3

2.1: thionyl chloride / 2 h / Reflux

2.2: 0.17 h

3.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 16 h / Reflux

4.1: potassium carbonate / acetonitrile / 20 °C

5.1: potassium hydroxide; water / methanol / 6 h / Reflux

5.2: pH 5 / Reflux

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; HATU / dichloromethane / 1 h / 20 °C

With N-Bromosuccinimide; thionyl chloride; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; HATU; potassium hydroxide; dibenzoyl peroxide; In methanol; tetrachloromethane; ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 91-56-5,1186480-61-4,84788-92-1
indole-2,3-dione

: 1336960-25-8
3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide / ethanol; water / 0.25 h

1.2: 1 h / Reflux

1.3: pH 3

2.1: thionyl chloride / 2 h / Reflux

2.2: 0.17 h

3.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 16 h / Reflux

4.1: potassium carbonate / acetonitrile / 20 °C

5.1: potassium hydroxide; water / methanol / 6 h / Reflux

5.2: pH 5 / Reflux

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; HATU / dichloromethane / 1 h / 20 °C

With N-Bromosuccinimide; thionyl chloride; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; HATU; potassium hydroxide; dibenzoyl peroxide; In methanol; tetrachloromethane; ethanol; dichloromethane; water; acetonitrile;