N-<6-<(4-amino-6,7-dimethoxyquinazolin-2-yl)methylamino>hexyl>-2-hydroxymethyl-N-methylbenzamide

Base Information

Chemical Name:N-<6-<(4-amino-6,7-dimethoxyquinazolin-2-yl)methylamino>hexyl>-2-hydroxymethyl-N-methylbenzamide
CAS No.:788141-76-4
Molecular Formula:C₂₆H₃₅N₅O₄
Molecular Weight:481.595
Hs Code.:

Synonyms:N-<6-<(4-amino-6,7-dimethoxyquinazolin-2-yl)methylamino>hexyl>-2-hydroxymethyl-N-methylbenzamide

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Chemical Property of N-<6-<(4-amino-6,7-dimethoxyquinazolin-2-yl)methylamino>hexyl>-2-hydroxymethyl-N-methylbenzamide

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Technology Process of N-<6-<(4-amino-6,7-dimethoxyquinazolin-2-yl)methylamino>hexyl>-2-hydroxymethyl-N-methylbenzamide

There total 3 articles about N-<6-<(4-amino-6,7-dimethoxyquinazolin-2-yl)methylamino>hexyl>-2-hydroxymethyl-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 217973-35-8
N-<6-<(4-amino-6,7-dimethoxyquinazolin-2-yl)methylamino>hexyl>-2-formyl-N-methylbenzamide

: 788141-76-4
N-<6-<(4-amino-6,7-dimethoxyquinazolin-2-yl)methylamino>hexyl>-2-hydroxymethyl-N-methylbenzamide

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 0 ℃; for 3h;
DOI:10.1021/jm9810654

Reference yield:

: 117886-88-1
2-formyl benzoyl chloride

: 788141-76-4
N-<6-<(4-amino-6,7-dimethoxyquinazolin-2-yl)methylamino>hexyl>-2-hydroxymethyl-N-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / Et₃N / dioxane / 24 h / Ambient temperature

2: 79 percent / NaBH₄ / ethanol / 3 h / 0 °C

With sodium tetrahydroborate; triethylamine; In 1,4-dioxane; ethanol;
DOI:10.1021/jm9810654

Reference yield:

: 119-67-5
o-carboxybenzaldehyde

: 788141-76-4
N-<6-<(4-amino-6,7-dimethoxyquinazolin-2-yl)methylamino>hexyl>-2-hydroxymethyl-N-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / SOCl₂ / benzene / 1 h / Heating

2: 87 percent / Et₃N / dioxane / 24 h / Ambient temperature

3: 79 percent / NaBH₄ / ethanol / 3 h / 0 °C

With sodium tetrahydroborate; thionyl chloride; triethylamine; In 1,4-dioxane; ethanol; benzene;
DOI:10.1021/jm9810654