2'-O-benzoyl-3'-O-(2-cyanoethoxy(diisopropylamino)phosphino)-5'-O-(4,4'-dimethoxytrityl)-2',3'-secouridine

Base Information

Chemical Name:2'-O-benzoyl-3'-O-(2-cyanoethoxy(diisopropylamino)phosphino)-5'-O-(4,4'-dimethoxytrityl)-2',3'-secouridine
CAS No.:1120329-48-7
Molecular Formula:C₄₆H₅₃N₄O₁₀P
Molecular Weight:852.921
Hs Code.:

Synonyms:2'-O-benzoyl-3'-O-(2-cyanoethoxy(diisopropylamino)phosphino)-5'-O-(4,4'-dimethoxytrityl)-2',3'-secouridine

Suppliers and Price of 2'-O-benzoyl-3'-O-(2-cyanoethoxy(diisopropylamino)phosphino)-5'-O-(4,4'-dimethoxytrityl)-2',3'-secouridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 6 raw suppliers

Chemical Property of 2'-O-benzoyl-3'-O-(2-cyanoethoxy(diisopropylamino)phosphino)-5'-O-(4,4'-dimethoxytrityl)-2',3'-secouridine

Chemical Property:

Purity/Quality:: 98%,99% , ^*data from raw suppliers

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Technology Process of 2'-O-benzoyl-3'-O-(2-cyanoethoxy(diisopropylamino)phosphino)-5'-O-(4,4'-dimethoxytrityl)-2',3'-secouridine

There total 2 articles about 2'-O-benzoyl-3'-O-(2-cyanoethoxy(diisopropylamino)phosphino)-5'-O-(4,4'-dimethoxytrityl)-2',3'-secouridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 2′-O-benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′,3′-secouridine

: 1120329-48-7
2'-O-benzoyl-3'-O-(2-cyanoethoxy(diisopropylamino)phosphino)-5'-O-(4,4'-dimethoxytrityl)-2',3'-secouridine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 0.666667h; Inert atmosphere;
DOI:10.1016/j.bmc.2009.06.045

Reference yield:

: 769-78-8,24991-32-0
vinyl benzoate

: 251943-33-6
5'-O-(4,4'-dimethoxytrityl)-2',3'-secouridine

: 1120329-48-7
2'-O-benzoyl-3'-O-(2-cyanoethoxy(diisopropylamino)phosphino)-5'-O-(4,4'-dimethoxytrityl)-2',3'-secouridine

Guidance literature:: Multi-step reaction with 2 steps

1: Theremomyces lanuginosus lipase immobilized on silica / toluene / 3 h / 40 - 42 °C / Enzymatic reaction

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 25 - 28 °C

With N-ethyl-N,N-diisopropylamine; In toluene; acetonitrile;
DOI:10.1080/15257770.2012.734424