CARBOMETHOXYCARBONYL-D-PRO-D-PHE BENZYL ESTER

Base Information

• Chemical Name: CARBOMETHOXYCARBONYL-D-PRO-D-PHE BENZYL ESTER
• CAS No.: 129988-00-7
• Molecular Formula: C₂₄H₂₆N₂O₆
• Molecular Weight: 438.48
• Mol file: 129988-00-7.mol

Synonyms:N-CARBOMETHOXYCARBONYL-D-PRO-D-PHE BENZYL ESTER;CH3OCOCO-DPRO-DPHE-O-BENZYL ESTER;CARBOMETHOXYCARBONYL-D-PRO-D-PHE BENZYL ESTER;CARBOMETHOXYCARBONYL-D-PRO-D-PHE-OBZL;Aids000799;Aids-000799;Cpf(dd);D-Phenylalanine, N-[1-(methoxyoxoacetyl)-D-prolyl]-, phenylmethyl ester

Chemical Property of CARBOMETHOXYCARBONYL-D-PRO-D-PHE BENZYL ESTER

Chemical Property:

• Refractive Index: 1.579
• PSA: 102.01000
• Density: 1.267 g/cm³
• LogP: 1.95010
• Storage Temp.: −20°C

Purity/Quality:

99% ^*data from raw suppliers

CARBOMETHOXYCARBONYL-D-PRO-D-PHE BENZYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CARBOMETHOXYCARBONYL-D-PRO-D-PHE BENZYL ESTER

There total 5 articles about CARBOMETHOXYCARBONYL-D-PRO-D-PHE BENZYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

monomethyl oxalyl chloride (5781-53-3) + (S)-3-Phenyl-2-[((S)-pyrrolidine-2-carbonyl)-amino]-propionic acid benzyl ester; compound with trifluoro-acetic acid → (S)-2-[((S)-1-Methoxyoxalyl-pyrrolidine-2-carbonyl)-amino]-3-phenyl-propionic acid benzyl ester (129988-00-7)

Guidance literature:

With pyridine; In dichloromethane; at 0 ℃; for 18h; Yield given;

DOI:10.1039/a800756j

Reference yield:

L-Phenylalanine benzyl ester (962-39-0) → (S)-2-[((S)-1-Methoxyoxalyl-pyrrolidine-2-carbonyl)-amino]-3-phenyl-propionic acid benzyl ester (129988-00-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 98.8 percent / DCC, TEA, PTS / CH₂Cl₂ / Ambient temperature

2: Et₂NH / dimethylformamide / 0.5 h / Ambient temperature

3: TEA / CH₂Cl₂ / 4 h

With TEA; pyridinium p-toluenesulfonate; diethylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

Fmoc-Pro-OH (71989-31-6) → (S)-2-[((S)-1-Methoxyoxalyl-pyrrolidine-2-carbonyl)-amino]-3-phenyl-propionic acid benzyl ester (129988-00-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 98.8 percent / DCC, TEA, PTS / CH₂Cl₂ / Ambient temperature

2: Et₂NH / dimethylformamide / 0.5 h / Ambient temperature

3: TEA / CH₂Cl₂ / 4 h

With TEA; pyridinium p-toluenesulfonate; diethylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

monomethyl oxalyl chloride

Pro-Phe-OBn

L-Phenylalanine benzyl ester

Fmoc-Pro-OH

Refernces

• 1、 Lacoux,Barragan,Dewynter,Leydet,Roque,Montero. "Synthesis and biological activity of acylated and telomerized peptides as potential HIV-fixation inhibitors". . p. 767 - 773. Retrieved 2007/10/03.