4-HYDROXY-6-MERCAPTOPYRAZOLO[3,4-D]PYRIMIDINE

Base Information

• Chemical Name: 4-HYDROXY-6-MERCAPTOPYRAZOLO[3,4-D]PYRIMIDINE
• CAS No.: 24521-76-4
• Molecular Formula: C5H4 N4 O S
• Molecular Weight: 168.179
• Hs Code.: 29335995
• Mol file: 24521-76-4.mol

Synonyms:1H-Pyrazolo[3,4-d]pyrimidin-4-ol,6-mercapto- (6CI,7CI,8CI); 1H-Pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione,6-thio-; 4-Hydroxy-6-mercaptopyrazolo[3,4-d]pyrimidine; B 103U; NSC 1391

Chemical Property of 4-HYDROXY-6-MERCAPTOPYRAZOLO[3,4-D]PYRIMIDINE

Chemical Property:

• Appearance/Colour: Off White Powder
• Vapor Pressure: 6.66E-05mmHg at 25°C
• Melting Point: >310°C
• Boiling Point: 334.3°Cat760mmHg
• PKA: 8.27±0.20(Predicted)
• Flash Point: 156°C
• PSA: 113.49000
• Density: 2.08g/cm³
• LogP: 0.34720
• Storage Temp.: -20°C Freezer
• Solubility.: Aqueous Base (Slightly), DMSO (Slightly)

Purity/Quality:

100% ^*data from raw suppliers

4-Hydroxy-6-mercaptopyrazolo[3,4-d]pyrimidine ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Hydroxy-6-mercaptopyrazolo[3,4-d]pyrimidine (cas# 24521-76-4) is a compound useful in organic synthesis.

Technology Process of 4-HYDROXY-6-MERCAPTOPYRAZOLO[3,4-D]PYRIMIDINE

There total 8 articles about 4-HYDROXY-6-MERCAPTOPYRAZOLO[3,4-D]PYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

potassium ethyl xanthogenate (140-89-6) + 5-amino-1H-pyrazole-4-carboxylic acid amide (5334-31-6) → 4-hydroxy-6-mercapto-1H-pyrazolo[3,4-d]pyrimidine (24521-76-4)

Guidance literature:

In N,N-dimethyl-formamide; at 120 ℃; for 6h;

DOI:10.1016/j.bioorg.2018.02.030

Reference yield: 70.0%

thiourea (17356-08-0) + 3-amino-4-pyrazole-carboxamide sulphate → 4-hydroxy-6-mercapto-1H-pyrazolo[3,4-d]pyrimidine (24521-76-4)

Guidance literature:

DOI:10.1016/S0223-5234(03)00065-5

Reference yield:

6-chloro-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (42754-97-2) + thiourea (17356-08-0) → 6-thioxo-1,5,6,7-tetrahydropyrazolo<3,4-d>pyrimidin-4-one (24521-76-4)

Guidance literature:

With ethanol;

upstream raw materials:

6-chloro-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

thiourea

3-amino-4-pyrazolocarboxamide hemisulfate

potassium ethyl xanthogenate

Downstream raw materials:

6-phenacylthio-pyrazolo<3,4-p>pyrimidine

6-[2-(4-Chloro-phenyl)-2-oxo-ethylsulfanyl]-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one

6-[2-(4-Bromo-phenyl)-2-oxo-ethylsulfanyl]-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one

6-[2-(4-Fluoro-phenyl)-2-oxo-ethylsulfanyl]-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one