2-hydroxy-6-oxo-cyclohex-1-enecarboxylic acid (2-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-thiazol-4-yl)-amide

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Chemical Name:2-hydroxy-6-oxo-cyclohex-1-enecarboxylic acid (2-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-thiazol-4-yl)-amide
CAS No.:1392237-04-5
Molecular Formula:C₂₂H₂₄F₃N₅O₄S
Molecular Weight:511.525
Hs Code.:

Synonyms:2-hydroxy-6-oxo-cyclohex-1-enecarboxylic acid (2-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-thiazol-4-yl)-amide

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Chemical Property of 2-hydroxy-6-oxo-cyclohex-1-enecarboxylic acid (2-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-thiazol-4-yl)-amide

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Technology Process of 2-hydroxy-6-oxo-cyclohex-1-enecarboxylic acid (2-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-thiazol-4-yl)-amide

There total 4 articles about 2-hydroxy-6-oxo-cyclohex-1-enecarboxylic acid (2-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-thiazol-4-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1392237-03-4
2-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-thiazole-4-carboxylic acid hydroxyamide

: 504-02-9
1,3-cylohexanedione

: 1392237-04-5
2-hydroxy-6-oxo-cyclohex-1-enecarboxylic acid (2-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-thiazol-4-yl)-amide

Guidance literature:: 2-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-thiazole-4-carboxylic acid hydroxyamide; With 1,1'-carbonyldiimidazole; In 1,2-dichloro-ethane; at 20 - 80 ℃;

1,3-cylohexanedione; With triethylamine; 1-butyl-3-methylimidazolium methylsulfate; In 1,2-dichloro-ethane; at 80 ℃; for 2h;

Reference yield:

: 345637-71-0
(5-methyl-3-trifluoromethylpyrazol-1-yl)acetic acid

: 1392237-04-5
2-hydroxy-6-oxo-cyclohex-1-enecarboxylic acid (2-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-thiazol-4-yl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.25 h / 20 °C

1.2: 20 °C

2.1: sodium hydroxide; water / tetrahydrofuran / 3 h / 20 °C

2.2: pH 2 - 3

3.1: 1,1'-carbonyldiimidazole / acetonitrile / 2 h / 20 °C

3.2: Reflux

4.1: 1,1'-carbonyldiimidazole / 1,2-dichloro-ethane / 20 - 80 °C

4.2: 2 h / 80 °C

With water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 922516-41-4
2-piperidin-4-yl-thiazole-4-carboxylic acid ethyl ester hydrochloride

: 1392237-04-5
2-hydroxy-6-oxo-cyclohex-1-enecarboxylic acid (2-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-thiazol-4-yl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.25 h / 20 °C

1.2: 20 °C

2.1: sodium hydroxide; water / tetrahydrofuran / 3 h / 20 °C

2.2: pH 2 - 3

3.1: 1,1'-carbonyldiimidazole / acetonitrile / 2 h / 20 °C

3.2: Reflux

4.1: 1,1'-carbonyldiimidazole / 1,2-dichloro-ethane / 20 - 80 °C

4.2: 2 h / 80 °C

With water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;