3-(5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)benzoic acid

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Chemical Name:3-(5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)benzoic acid
CAS No.:102053-59-8
Molecular Formula:C₁₇H₂₁N₃O₄S
Molecular Weight:363.437
Hs Code.:

Synonyms:3-(5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)benzoic acid

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Chemical Property of 3-(5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)benzoic acid

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Technology Process of 3-(5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)benzoic acid

There total 5 articles about 3-(5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 99-05-8,159139-79-4
meta-aminobenzoic acid

: 58-85-5,22879-79-4
biotin

: 102053-59-8
3-(5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)benzoic acid

Guidance literature:: biotin; With tributyl-amine; isobutyl chloroformate; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

meta-aminobenzoic acid; In N,N-dimethyl-formamide; at 5 ℃; for 2h;
DOI:10.1021/ja0476718

Reference yield:

: methyl 3-(5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)benzoate

: 102053-59-8
3-(5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)benzoic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 618-95-1
methyl 3-nitrobenzoate

: 102053-59-8
3-(5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: tin(II) chloride dihdyrate; ethanol / 2 h / Reflux

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3: lithium hydroxide; water / tetrahydrofuran / 20 °C

With tin(II) chloride dihdyrate; ethanol; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane;