Technology Process of Vincantril
There total 11 articles about Vincantril which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 6h;
DOI:10.1021/jo050503t
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 99 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating
2: 75 percent / Et3N / CH2Cl2 / 6 h / 20 °C
3: 83 percent / Et3N / Pd(OAc)2 / acetonitrile / 2 h / 20 °C
4: 94 percent / Sn(OTf)2 / CH2Cl2 / 2 h / 0 °C
5: 80 percent / PhSK / acetonitrile / 48 h / 20 °C
6: 100 percent / CH2Cl2 / 6 h / Heating
7: 82 percent / Hoveyda-Grubbs catalyst / toluene / 48 h / 60 °C
8: 99 percent / H2 / PtO2 / methanol / 1 h / 760 Torr
9: 39 percent / NaHMDS / toluene / 2 h / 20 °C
10: 88 percent / TFA / CH2Cl2 / 6 h / 20 °C
With
lithium aluminium tetrahydride; tin(II) trifluoromethanesulfonate; hydrogen; sodium hexamethyldisilazane; (2E)-3-(4-hydroxyphenyl-3-methoxyphenyl)-1-phenylprop-2-en-1-one; triethylamine; trifluoroacetic acid;
platinum(IV) oxide; palladium diacetate; [1,3-bis-(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(O-isopropoxyphenylmethylene)ruthenium;
In
tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile;
DOI:10.1021/jo050503t
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 100 percent / CH2Cl2 / 6 h / Heating
2: 82 percent / Hoveyda-Grubbs catalyst / toluene / 48 h / 60 °C
3: 99 percent / H2 / PtO2 / methanol / 1 h / 760 Torr
4: 39 percent / NaHMDS / toluene / 2 h / 20 °C
5: 88 percent / TFA / CH2Cl2 / 6 h / 20 °C
With
hydrogen; sodium hexamethyldisilazane; trifluoroacetic acid;
platinum(IV) oxide; [1,3-bis-(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(O-isopropoxyphenylmethylene)ruthenium;
In
methanol; dichloromethane; toluene;
DOI:10.1021/jo050503t
