4-benzyl-5-[hydroxy(phenyl)methyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione

Base Information

• Chemical Name: 4-benzyl-5-[hydroxy(phenyl)methyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione
• CAS No.: 642075-27-2
• Molecular Formula: C₁₆H₁₅N₃OS
• Molecular Weight: 297.381

Synonyms:4-benzyl-5-[hydroxy(phenyl)methyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione

Chemical Property of 4-benzyl-5-[hydroxy(phenyl)methyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione

Chemical Property:

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Technology Process of 4-benzyl-5-[hydroxy(phenyl)methyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione

There total 2 articles about 4-benzyl-5-[hydroxy(phenyl)methyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(RS)-methyl mandelate (4358-87-6) → 4-benzyl-5-[hydroxy(phenyl)methyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione (642075-27-2)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / 12 h / Reflux

2: ethanol / 2 h / Reflux

3: sodium hydroxide / 3 h / Reflux

With hydrazine hydrate; sodium hydroxide; In ethanol;

DOI:10.2174/157018081131000074

Reference yield:

2-hydroxy-2-phenylacetohydrazide (2443-66-5) → 4-benzyl-5-[hydroxy(phenyl)methyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione (642075-27-2)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 2 h / Reflux

2: sodium hydroxide / 3 h / Reflux

With sodium hydroxide; In ethanol;

DOI:10.2174/157018081131000074

Reference yield: 76.0%

4-benzyl-5-[hydroxy(phenyl)methyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione (642075-27-2) + benzyl chloride (100-44-7) → 4-benzyl-3-(benzylsulfanyl)-5-[hydroxy-(phenyl)methyl]-4H-1,2,4-triazole

Guidance literature:

With potassium carbonate; In acetone; for 3h; Reflux;

DOI:10.2174/157018081131000074

upstream raw materials:

(RS)-methyl mandelate

2-hydroxy-2-phenylacetohydrazide

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