(S)-2-((tert-butoxycarbonyl)amino)-6-((((1-oxy-2,2,5,5-tetramethylpyrroline-3-yl)methoxy)carbonyl)amino)hexanoic acid

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Chemical Name:(S)-2-((tert-butoxycarbonyl)amino)-6-((((1-oxy-2,2,5,5-tetramethylpyrroline-3-yl)methoxy)carbonyl)amino)hexanoic acid
CAS No.:1536470-16-2
Molecular Formula:C₂₁H₃₆N₃O₇
Molecular Weight:442.533
Hs Code.:

Synonyms:(S)-2-((tert-butoxycarbonyl)amino)-6-((((1-oxy-2,2,5,5-tetramethylpyrroline-3-yl)methoxy)carbonyl)amino)hexanoic acid

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Chemical Property of (S)-2-((tert-butoxycarbonyl)amino)-6-((((1-oxy-2,2,5,5-tetramethylpyrroline-3-yl)methoxy)carbonyl)amino)hexanoic acid

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Technology Process of (S)-2-((tert-butoxycarbonyl)amino)-6-((((1-oxy-2,2,5,5-tetramethylpyrroline-3-yl)methoxy)carbonyl)amino)hexanoic acid

There total 2 articles about (S)-2-((tert-butoxycarbonyl)amino)-6-((((1-oxy-2,2,5,5-tetramethylpyrroline-3-yl)methoxy)carbonyl)amino)hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 74124-79-1
di(succinimido) carbonate

: 55738-75-5
(2,5-dihydro-2,2,5,5-tetramethyl-1-oxyl-1H-pyrrol-3-yl)methanol

: 13734-28-6
Boc-Lys-OH

: 1536470-16-2
(S)-2-((tert-butoxycarbonyl)amino)-6-((((1-oxy-2,2,5,5-tetramethylpyrroline-3-yl)methoxy)carbonyl)amino)hexanoic acid

Guidance literature:: di(succinimido) carbonate; (2,5-dihydro-2,2,5,5-tetramethyl-1-oxyl-1H-pyrrol-3-yl)methanol; With triethylamine; In acetonitrile; at 0 - 20 ℃; for 13h; Inert atmosphere;

Boc-Lys-OH; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 20h; Inert atmosphere;
DOI:10.1016/bs.mie.2015.05.023

Reference yield: 75.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: 55738-75-5
(2,5-dihydro-2,2,5,5-tetramethyl-1-oxyl-1H-pyrrol-3-yl)methanol

: 13734-28-6
Boc-Lys-OH

: 1536470-16-2
(S)-2-((tert-butoxycarbonyl)amino)-6-((((1-oxy-2,2,5,5-tetramethylpyrroline-3-yl)methoxy)carbonyl)amino)hexanoic acid

Guidance literature:: bis(trichloromethyl) carbonate; (2,5-dihydro-2,2,5,5-tetramethyl-1-oxyl-1H-pyrrol-3-yl)methanol; In tetrahydrofuran; at 20 ℃; for 18h; Inert atmosphere; Cooling with ice;

Boc-Lys-OH; With sodium hydroxide; In tetrahydrofuran; for 24h; Inert atmosphere;
DOI:10.1021/ja411535q