(6R,7R)-7-((R)-2-Amino-2-benzo[b]thiophen-5-yl-acetylamino)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Base Information

• Chemical Name: (6R,7R)-7-((R)-2-Amino-2-benzo[b]thiophen-5-yl-acetylamino)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester
• CAS No.: 98799-98-5
• Molecular Formula: C₂₅H₂₂N₄O₆S₂
• Molecular Weight: 538.605

Synonyms:(6R,7R)-7-((R)-2-Amino-2-benzo[b]thiophen-5-yl-acetylamino)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Chemical Property of (6R,7R)-7-((R)-2-Amino-2-benzo[b]thiophen-5-yl-acetylamino)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6R,7R)-7-((R)-2-Amino-2-benzo[b]thiophen-5-yl-acetylamino)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

There total 12 articles about (6R,7R)-7-((R)-2-Amino-2-benzo[b]thiophen-5-yl-acetylamino)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(6R,7R)-7-((R)-2-Benzo[b]thiophen-5-yl-2-tert-butoxycarbonylamino-acetylamino)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester (95361-87-8) → (6R,7R)-7-((R)-2-Amino-2-benzo[b]thiophen-5-yl-acetylamino)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester (98799-98-5)

Guidance literature:

With sodium hydrogencarbonate; toluene-4-sulfonic acid; In acetonitrile; for 0.5h; Ambient temperature;

DOI:10.1021/jm00150a023

Reference yield:

4-keto-4,5,6,7-tetrahydrothianaphthene (13414-95-4) → (6R,7R)-7-((R)-2-Amino-2-benzo[b]thiophen-5-yl-acetylamino)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester (98799-98-5)

Guidance literature:

Multi-step reaction with 10 steps

1: 1.) diisopropylamine, n-BuLi / 1.) THF, hexane, -70 deg C, 0.5 h, 2.) THF, hexane, from -70 deg C to room temp., 18 h

2: 91 percent / NaBH₄ / 20 h / Ambient temperature

3: 29 percent / p-TsOH / toluene / 0.03 h / Heating

4: 36 percent / DDQ / benzene / 0.5 h

5: 31 percent / NaOEt, butyl nitrite / ethanol / Ambient temperature

6: 55 percent / formic acid, zinc / ethanol; H₂O / a) 0 deg C, 3 h, b) room temp., overnight

7: 2.22 N NaOH / ethanol

8: 87 percent / Et₃N / ethanol; H₂O; dioxane

9: 100 mg / N-(ethoxycarbonyl)-2-ethoxy-1,2-dihydroquinoline (EEDQ) / tetrahydrofuran; acetonitrile / 5.5 h / Ambient temperature

10: 73 percent / p-toluenesulfonic acid, NaHCO₃ / acetonitrile / 0.5 h / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; n-butyllithium; formic acid; n-Butyl nitrite; sodium ethanolate; sodium hydrogencarbonate; toluene-4-sulfonic acid; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; zinc; In tetrahydrofuran; 1,4-dioxane; ethanol; water; toluene; acetonitrile; benzene;

DOI:10.1021/jm00150a023

Reference yield:

4,5,6,7-tetrahydro-α,4-dioxobenzothiophene-5-acetic acid ethyl ester (14779-31-8) → (6R,7R)-7-((R)-2-Amino-2-benzo[b]thiophen-5-yl-acetylamino)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester (98799-98-5)

Guidance literature:

Multi-step reaction with 8 steps

1: 27 percent / sodium borohydride / ethanol / 4 h / 0 °C

2: 21 percent / p-toluenesulfonic acid / toluene / 2 h / Heating

3: 31 percent / NaOEt, butyl nitrite / ethanol / Ambient temperature

4: 55 percent / formic acid, zinc / ethanol; H₂O / a) 0 deg C, 3 h, b) room temp., overnight

5: 2.22 N NaOH / ethanol

6: 87 percent / Et₃N / ethanol; H₂O; dioxane

7: 100 mg / N-(ethoxycarbonyl)-2-ethoxy-1,2-dihydroquinoline (EEDQ) / tetrahydrofuran; acetonitrile / 5.5 h / Ambient temperature

8: 73 percent / p-toluenesulfonic acid, NaHCO₃ / acetonitrile / 0.5 h / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; formic acid; n-Butyl nitrite; sodium ethanolate; sodium hydrogencarbonate; toluene-4-sulfonic acid; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; zinc; In tetrahydrofuran; 1,4-dioxane; ethanol; water; toluene; acetonitrile;

DOI:10.1021/jm00150a023

upstream raw materials:

(6R,7R)-7-((R)-2-Benzo[b]thiophen-5-yl-2-tert-butoxycarbonylamino-acetylamino)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

4-keto-4,5,6,7-tetrahydrothianaphthene

5-(carboethoxymethyl)-6,7-dihydrothianaphthene

benzothiophene-5-acetic acid ethyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 98799-98-5 (6R,7R)-7-((R)-2-Amino-2-benzo[b]thiophen-5-yl-acetylamino)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send