2,3-dihydro-2-ethyl-5-fluoro-2-[(4-methylphenyl)sulfonyl]-1H-inden-1-imine

Base Information

• Chemical Name: 2,3-dihydro-2-ethyl-5-fluoro-2-[(4-methylphenyl)sulfonyl]-1H-inden-1-imine
• CAS No.: 1444444-45-4
• Molecular Formula: C₁₈H₁₈FNO₂S
• Molecular Weight: 331.411

Synonyms:2,3-dihydro-2-ethyl-5-fluoro-2-[(4-methylphenyl)sulfonyl]-1H-inden-1-imine

Chemical Property of 2,3-dihydro-2-ethyl-5-fluoro-2-[(4-methylphenyl)sulfonyl]-1H-inden-1-imine

Chemical Property:

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Technology Process of 2,3-dihydro-2-ethyl-5-fluoro-2-[(4-methylphenyl)sulfonyl]-1H-inden-1-imine

There total 1 articles about 2,3-dihydro-2-ethyl-5-fluoro-2-[(4-methylphenyl)sulfonyl]-1H-inden-1-imine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

1-(1-isocyanopropane-1-sulfonyl)-4-methylbenzene (58379-81-0) + 2-bromo-5-fluorobenzyl bromide (112399-50-5) → 2,3-dihydro-2-ethyl-5-fluoro-2-[(4-methylphenyl)sulfonyl]-1H-inden-1-imine (1444444-45-4)

Guidance literature:

1-(1-isocyanopropane-1-sulfonyl)-4-methylbenzene; With tert.-butyl lithium; In tetrahydrofuran; hexane; at -78 ℃; for 1.5h; Inert atmosphere;

2-bromo-5-fluorobenzyl bromide; In tetrahydrofuran; hexane; at -78 ℃; for 1.5h; Inert atmosphere;

DOI:10.1021/ol401433x

Reference yield: 60.0%

2,3-dihydro-2-ethyl-5-fluoro-2-[(4-methylphenyl)sulfonyl]-1H-inden-1-imine (1444444-45-4) → (E)-2-(but-1-en-1-yl)-4-fluorobenzonitrile (1444444-00-1)

Guidance literature:

With potassium tert-butylate; In tert-butyl alcohol; for 2h; Reflux;

DOI:10.1021/ol401433x

upstream raw materials:

1-(1-isocyanopropane-1-sulfonyl)-4-methylbenzene

2-bromo-5-fluorobenzyl bromide

Downstream raw materials:

(E)-2-(but-1-en-1-yl)-4-fluorobenzonitrile

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