Technology Process of (3S,5S)-2,2,5-trimethyl-9-(methylamino)-9-oxononan-3-yl (2R)-6-((4-methoxybenzyl)oxy)-2-methylhexanoate
There total 12 articles about (3S,5S)-2,2,5-trimethyl-9-(methylamino)-9-oxononan-3-yl (2R)-6-((4-methoxybenzyl)oxy)-2-methylhexanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(R)-6-((4-methoxybenzyl)oxy)-2-methylhexanoic acid;
With
2,4,6-trichlorobenzoyl chloride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran;
at 20 ℃;
for 3h;
Inert atmosphere;
(5S,7S)-7-hydroxy-N,5,8,8-tetramethylnonanamide;
With
dmap;
In
tetrahydrofuran; toluene;
at 20 ℃;
for 12h;
Inert atmosphere;
DOI:10.1021/jo301121f
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate
2.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / dichloromethane / 6 h / 20 °C / Inert atmosphere
3.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / water; tert-butyl alcohol / 0.75 h / 20 °C / Inert atmosphere
4.1: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C / Inert atmosphere
5.1: 2,4,6-trichlorobenzoyl chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere
5.2: 12 h / 20 °C / Inert atmosphere
With
dmap; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; 2,4,6-trichlorobenzoyl chloride; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; tert-butyl alcohol;
DOI:10.1021/jo301121f
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / dichloromethane / 6 h / 20 °C / Inert atmosphere
2.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / water; tert-butyl alcohol / 0.75 h / 20 °C / Inert atmosphere
3.1: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C / Inert atmosphere
4.1: 2,4,6-trichlorobenzoyl chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere
4.2: 12 h / 20 °C / Inert atmosphere
With
dmap; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; 2,4,6-trichlorobenzoyl chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/jo301121f
