7-({2-[(4-Chloro-phenyl)-phenyl-methoxy]-ethyl}-methyl-amino)-heptanenitrile

Base Information

• Chemical Name: 7-({2-[(4-Chloro-phenyl)-phenyl-methoxy]-ethyl}-methyl-amino)-heptanenitrile
• CAS No.: 175692-20-3
• Molecular Formula: C₂₃H₂₉ClN₂O
• Molecular Weight: 384.949
• Mol file: 175692-20-3.mol

Synonyms:7-({2-[(4-Chloro-phenyl)-phenyl-methoxy]-ethyl}-methyl-amino)-heptanenitrile

Chemical Property of 7-({2-[(4-Chloro-phenyl)-phenyl-methoxy]-ethyl}-methyl-amino)-heptanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-({2-[(4-Chloro-phenyl)-phenyl-methoxy]-ethyl}-methyl-amino)-heptanenitrile

There total 4 articles about 7-({2-[(4-Chloro-phenyl)-phenyl-methoxy]-ethyl}-methyl-amino)-heptanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

7-bromo-heptanonitrile (20965-27-9) + {2-[(4-Chloro-phenyl)-phenyl-methoxy]-ethyl}-methyl-amine (175692-17-8) → 7-({2-[(4-Chloro-phenyl)-phenyl-methoxy]-ethyl}-methyl-amino)-heptanenitrile (175692-20-3)

Guidance literature:

With potassium carbonate; In acetonitrile; at 90 ℃;

DOI:10.1002/ardp.19963290206

Reference yield:

(4-chlorophenyl)phenylmethanol (119-56-2) → 7-({2-[(4-Chloro-phenyl)-phenyl-methoxy]-ethyl}-methyl-amino)-heptanenitrile (175692-20-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 72 percent / NaH / toluene / 5 h / Heating

2: Na₂CO₃ / 1,2-dichloro-ethane / 1) 0 deg C, 10 min, 2) reflux, 2 h

3: 1) CH₃OH, 2) NaOH / 1) r.t., 50 deg C, 2 h, 2) water

4: 84 percent / K₂CO₃ / acetonitrile / 90 °C

With methanol; sodium hydroxide; sodium hydride; sodium carbonate; potassium carbonate; In 1,2-dichloro-ethane; toluene; acetonitrile;

DOI:10.1002/ardp.19963290206

Reference yield:

(+/-)-[2-(4-chloro-benzhydryloxy)-ethyl]-dimethyl-amine (22808-17-9) → 7-({2-[(4-Chloro-phenyl)-phenyl-methoxy]-ethyl}-methyl-amino)-heptanenitrile (175692-20-3)

Guidance literature:

Multi-step reaction with 3 steps

1: Na₂CO₃ / 1,2-dichloro-ethane / 1) 0 deg C, 10 min, 2) reflux, 2 h

2: 1) CH₃OH, 2) NaOH / 1) r.t., 50 deg C, 2 h, 2) water

3: 84 percent / K₂CO₃ / acetonitrile / 90 °C

With methanol; sodium hydroxide; sodium carbonate; potassium carbonate; In 1,2-dichloro-ethane; acetonitrile;

DOI:10.1002/ardp.19963290206

upstream raw materials:

7-bromo-heptanonitrile

{2-[(4-Chloro-phenyl)-phenyl-methoxy]-ethyl}-methyl-amine

(4-chlorophenyl)phenylmethanol

(+/-)-[2-(4-chloro-benzhydryloxy)-ethyl]-dimethyl-amine

Downstream raw materials:

N¹-{2-[(4-Chloro-phenyl)-phenyl-methoxy]-ethyl}-N¹-methyl-heptane-1,7-diamine