(2R,3S)-(-)-2-methyl-N-(p-toluenesulfonyl)-3-aminopentanol

Base Information

Chemical Name:(2R,3S)-(-)-2-methyl-N-(p-toluenesulfonyl)-3-aminopentanol
CAS No.:193979-99-6
Molecular Formula:C₁₃H₂₁NO₃S
Molecular Weight:271.381
Hs Code.:

Synonyms:(2R,3S)-(-)-2-methyl-N-(p-toluenesulfonyl)-3-aminopentanol

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Chemical Property of (2R,3S)-(-)-2-methyl-N-(p-toluenesulfonyl)-3-aminopentanol

Chemical Property:

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Technology Process of (2R,3S)-(-)-2-methyl-N-(p-toluenesulfonyl)-3-aminopentanol

There total 9 articles about (2R,3S)-(-)-2-methyl-N-(p-toluenesulfonyl)-3-aminopentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 943241-48-3
(2R,3S)-(-)-2-methyl-N-(p-toluenesulfonyl)-3-aminopentanal

: 193979-99-6
(2R,3S)-(-)-2-methyl-N-(p-toluenesulfonyl)-3-aminopentanol

Guidance literature:: With lithium triethylborohydride; In tetrahydrofuran; dichloromethane; at -78 ℃; for 1.5h;
DOI:10.1021/ol0708166

Reference yield:

: 943241-42-7
(S_S,2R,3S)-(+)-N-methoxy-N,2-dimethyl-3-(2,4,6-triisopropylphenylsulfinylamino)pentanamide

: 193979-99-6
(2R,3S)-(-)-2-methyl-N-(p-toluenesulfonyl)-3-aminopentanol

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / HCl / methanol; diethyl ether / 0.5 h / 0 °C

2: 76 percent / Et₃N; DMAP / CH₂Cl₂ / 0 °C

3: 71 percent / DIBAL-H / tetrahydrofuran; CH₂Cl₂ / 0.17 h / -78 °C

4: 99 percent / LiEt₃BH / CH₂Cl₂; tetrahydrofuran / 1.5 h / -78 °C

With hydrogenchloride; dmap; diisobutylaluminium hydride; lithium triethylborohydride; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1021/ol0708166

Reference yield:

: 943241-45-0
(2R,3S)-(-)-3-amino-N-methoxy-N,2-dimethylpentanamide

: 193979-99-6
(2R,3S)-(-)-2-methyl-N-(p-toluenesulfonyl)-3-aminopentanol

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / Et₃N; DMAP / CH₂Cl₂ / 0 °C

2: 71 percent / DIBAL-H / tetrahydrofuran; CH₂Cl₂ / 0.17 h / -78 °C

3: 99 percent / LiEt₃BH / CH₂Cl₂; tetrahydrofuran / 1.5 h / -78 °C

With dmap; diisobutylaluminium hydride; lithium triethylborohydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol0708166